file PSI-MOD.obo abd5035e40d62c432afde15e3a48f279 1208713092

1.2 20:04:2008 18:36 luisa OBO-Edit 1.101 PSI-MOD DeltaMass-label "Label from MS DeltaMass" EXACT PSI-MOD-alternate "Alternate label curated by PSI-MOD" EXACT PSI-MOD-short "Unique short label curated by PSI-MOD" EXACT PSI-MS-label "Agreed label from MS community" RELATED RESID-alternate "Alternate label from RESID" EXACT RESID-misnomer "Misnomer label from RESID" EXACT RESID-systematic "Systematic name from RESID" EXACT UniMod-description "Description from UniMod" RELATED UniMod-interim "Interim label from UniMod" RELATED UniProt-feature "Protein feature label from UniProtKB" EXACT PSI-MOD version: 1.005 Annotation note 1 - "[PSI-MOD:ref]" is to be replaced by the PubMed Id of the PSI-MOD paper when it is available. Annotation note 2 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by the quoted tag "resulting". When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate or on secondary modifications that do not change the nature of the primary modification, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the quoted tag "variant". Annotation note 3 - When an entry in the UniMod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the UniMod cross-reference followed by the quoted tag "site". Annotation note 4 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for elements without isotope indicators in the formulas. Annotation note 5 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. Annotation note 6 - The synonym cross-reference "PSI-MOD:old name" has been replaced by "PSI-MOD:alternate name". Synonym type - The synonyms that are unique for a PSI-MOD entry are EXACT those synonyms that are assigned to multiple terms are RELATED

MOD:00000 protein modification Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. ref PSI-MOD PSI-MOD slim ModRes PSI-MOD 1 MOD:00001 alkylated residue A protein modification that effectively replaces a hydrogen atom with an alkyl group. ref PSI-MOD PSI-MOD slim AlkylRes MOD:01156 PSI-MOD MOD:00002 O-glycosyl-L-serine A protein modification that effectively forms an O3-glycosylserine. ref PSI-MOD PSI-MOD slim OGlycoSer DiffAvg 146.14 DiffFormula C 6 H 10 N 0 O 4 DiffMono 146.057909 Formula C 9 H 15 N 1 O 6 MassAvg 233.22 MassMono 233.089937 Origin S Source Natural TermSpec none MOD:00396 MOD:00916 PSI-MOD MOD:00003 UniMod Entry from UniMod. ref PSI-MOD MOD:00032 PSI-MOD MOD:00004 artifact Artifact entry from UniMod. ref PSI-MOD MOD:00003 PSI-MOD MOD:00005 O-glycosyl-L-threonine A protein modification that effectively forms a O3-glycosylthreonine. ref PSI-MOD PSI-MOD slim OGlycoThr DiffAvg 146.14 DiffFormula C 6 H 10 N 0 O 4 DiffMono 146.057909 Formula C 10 H 17 N 1 O 6 MassAvg 247.25 MassMono 247.105587 Origin T Source Natural TermSpec none MOD:00396 MOD:00917 PSI-MOD MOD:00006 N-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. ref PSI-MOD PSI-MOD slim NGlycoRes MOD:00693 PSI-MOD MOD:00007 selenium substitution for sulfur A protein modification that effectively substitutes a selenium atom for a sulfur atom. 12148805 PubMed 162 UniMod Delta:S(-1)Se(1) Se(S)Res Selenium replaces sulphur DiffAvg 46.89 DiffFormula C 0 H 0 N 0 O 0 S -1 Se 1 DiffMono 47.944451 Formula none MassAvg none MassMono none Origin X Source Artifact TermSpec none MOD:00745 PSI-MOD MOD:00008 common Entry from UniMod representing one or more entries in RESID. ref PSI-MOD MOD:00003 PSI-MOD MOD:00009 natural residue A protein modification that inserts or replaces a residue with a natural, unmodified or encoded residue. ref PSI-MOD 6692818 PubMed PSI-MOD slim Res MOD:01157 PSI-MOD MOD:00010 L-alanine residue A protein modification that inserts or replaces a residue with an L-alanine residue. 29948 ChEBI 0 DeltaMass 6692818 PubMed AA0001 RESID PSI-MOD slim (S)-2-aminopropanoic acid 2-aminopropionic acid Ala alpha-alanine alpha-aminopropionic acid DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin A Source Natural TermSpec none MOD:00009 MOD:00570 MOD:00859 PSI-MOD MOD:00011 L-arginine residue A protein modification that inserts or replaces a residue with an L-arginine residue. 29952 ChEBI 0 DeltaMass 518876 PubMed 6692818 PubMed AA0002 RESID PSI-MOD slim (S)-2-amino-5-(carbamimidamido)pentanoic acid 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid 2-amino-5-guanidinopentanoic acid 2-amino-5-guanidinovaleric acid alpha-amino-delta-guanidinovaleric acid Arg DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 12 N 4 O 1 MassAvg 156.19 MassMono 156.101111 Origin R Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00012 L-asparagine residue A protein modification that inserts or replaces a residue with an L-asparagine residue. 29956 ChEBI 0 DeltaMass 15736973 PubMed 5681232 PubMed 6692818 PubMed 9789001 PubMed AA0003 RESID PSI-MOD slim (S)-2-amino-4-butanediamic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-aminosuccinamic acid alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid Asn aspartic acid beta-amide DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin N Source Natural TermSpec none MOD:00009 MOD:00859 PSI-MOD MOD:00013 L-aspartic acid residue A protein modification that inserts or replaces a residue with an L-aspartic acid residue. 29958 ChEBI 0 DeltaMass 1097438 PubMed 339692 PubMed 4399050 PubMed 5764436 PubMed 6692818 PubMed 8089117 PubMed 9521123 PubMed 9582379 PubMed AA0004 RESID PSI-MOD slim (S)-2-aminobutanedioic acid aminosuccinic acid Asp DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin D Source Natural TermSpec none MOD:00009 MOD:00859 PSI-MOD MOD:00014 L-cysteine residue A protein modification that inserts or replaces a residue with an L-cysteine residue. 29950 ChEBI 0 DeltaMass 1310545 PubMed 15790858 PubMed 3447159 PubMed 6692818 PubMed 7338899 PubMed AA0005 RESID From DeltaMass: Average Mass: 121 PSI-MOD slim (R)-2-amino-3-sulfanylpropanoic acid (R)-cysteine 2-amino-3-mercaptopropanoic acid 2-amino-3-mercaptopropionic acid 3-mercapto-L-alanine alpha-amino-beta-mercaptopropanoic acid alpha-amino-beta-mercaptopropionic acid alpha-amino-beta-thiolpropionic acid beta-mercaptoalanine Cys Cysteine (C, Cys) half-cystine L-(+)-cysteine thioserine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 S 1 MassAvg 103.14 MassMono 103.009184 Origin C Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00015 L-glutamic acid residue A protein modification that inserts or replaces a residue with an L-glutamic acid residue. 29972 ChEBI 0 DeltaMass 1881881 PubMed 4565668 PubMed 4922541 PubMed 6692818 PubMed 9326660 PubMed 957425 PubMed AA0006 RESID PSI-MOD slim (S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid alpha-aminoglutaric acid Glu glutaminic acid DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 7 N 1 O 3 MassAvg 129.11 MassMono 129.042593 Origin E Source Natural TermSpec none MOD:00009 MOD:00859 PSI-MOD MOD:00016 L-glutamine residue A protein modification that inserts or replaces a residue with an L-glutamine residue. 30011 ChEBI 0 DeltaMass 3340166 PubMed 6692818 PubMed 9342308 PubMed AA0007 RESID PSI-MOD slim (S)-2-amino-5-pentanediamic acid 2,5-diamino-5-oxopentanoic acid 2-amino-4-carbamoylbutanoic acid 2-aminoglutaramic acid alpha-amino-gamma-carbamylbutyric acid Gln glutamic acid 5-amide glutamic acid gamma-amide glutamide DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 8 N 2 O 2 MassAvg 128.13 MassMono 128.058578 Origin Q Source Natural TermSpec none MOD:00009 MOD:00894 PSI-MOD MOD:00017 glycine residue A protein modification that inserts or replaces a residue with a glycine residue. 29947 ChEBI 0 DeltaMass 1310545 PubMed 6692818 PubMed AA0008 RESID From DeltaMass: Average Mass: 75 PSI-MOD slim aminoacetic acid aminoethanoic acid Gly glycocoll DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 2 H 3 N 1 O 1 MassAvg 57.05 MassMono 57.021464 Origin G Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00018 L-histidine residue A protein modification that inserts or replaces a residue with an L-histidine residue. 29979 ChEBI 0 DeltaMass 14342316 PubMed 2722967 PubMed 512 PubMed 5460889 PubMed 6129252 PubMed 6692818 PubMed 6876174 PubMed AA0009 RESID PSI-MOD slim (S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid 4-(2-amino-2-carboxyethyl)imidazole alpha-amino-beta-(4-imidazole)propionic acid His DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 7 N 3 O 1 MassAvg 137.14 MassMono 137.058912 Origin H Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00019 L-isoleucine residue A protein modification that inserts or replaces a residue with an L-isoleucine residue. 30009 ChEBI 0 DeltaMass 6692818 PubMed AA0010 RESID PSI-MOD slim (2S,3S)-2-amino-3-methylpentanoic acid alpha-amino-beta-methylvaleric acid Ile Isoleucyl L-threo-isoleucine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin I Source Natural TermSpec none MOD:00009 MOD:00306 PSI-MOD MOD:00020 L-leucine residue A protein modification that inserts or replaces a residue with an L-leucine residue. 30006 ChEBI 0 DeltaMass 11478885 PubMed 6692818 PubMed AA0011 RESID PSI-MOD slim (S)-2-amino-4-methylpentanoic acid alpha-amino-gamma-methylvaleric acid alpha-aminoisocaproic acid Leu DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin L Source Natural TermSpec none MOD:00009 MOD:00306 PSI-MOD MOD:00021 L-lysine residue A protein modification that inserts or replaces a residue with an L-lysine residue. 29967 ChEBI 0 DeltaMass 3106962 PubMed 6120171 PubMed 6692818 PubMed AA0012 RESID PSI-MOD slim (S)-2,6-diaminohexanoic acid alpha,epsilon-diaminocaproic acid Lys DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 12 N 2 O 1 MassAvg 128.17 MassMono 128.094963 Origin K Source Natural TermSpec none MOD:00009 MOD:00893 PSI-MOD MOD:00022 L-methionine residue A protein modification that inserts or replaces a residue with an L-methionine residue. 29983 ChEBI 0 DeltaMass 6411710 PubMed 6692818 PubMed AA0013 RESID From DeltaMass: Average Mass: 149 PSI-MOD slim (S)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid alpha-amino-gamma-methylmercaptobutyric acid alpha-amino-gamma-methylthiobutyric acid gamma-methylthio-alpha-aminobutyric acid L-(-)-methionine Met S-methyl-L-homocysteine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.20 MassMono 131.040485 Origin M Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00023 L-phenylalanine residue A protein modification that inserts or replaces a residue with an L-phenylalanine residue. 29997 ChEBI 0 DeltaMass 6692818 PubMed AA0014 RESID PSI-MOD slim (S)-2-amino-3-phenylpropanoic acid alpha-amino-beta-phenylpropionic acid Phe DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 1 MassAvg 147.17 MassMono 147.068414 Origin F Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00024 L-proline residue A protein modification that inserts or replaces a residue with an L-proline residue. 30017 ChEBI 0 DeltaMass 6692818 PubMed 8547259 PubMed AA0015 RESID PSI-MOD slim (S)-2-pyrrolidinecarboxylic acid Pro pyrrolidine-2-carboxylic acid DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 7 N 1 O 1 MassAvg 97.12 MassMono 97.052764 Origin P Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00025 L-serine residue A protein modification that inserts or replaces a residue with an L-serine residue. 29999 ChEBI 0 DeltaMass 4399050 PubMed 6692818 PubMed AA0016 RESID PSI-MOD slim (S)-2-amino-3-hydroxypropanoic acid 3-hydroxy-L-alanine alpha-amino-beta-hydroxypropionic acid beta-hydroxyalanine Ser DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin S Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00026 L-threonine residue A protein modification that inserts or replaces a residue with an L-threonine residue. 30013 ChEBI 0 DeltaMass 2989287 PubMed 6692818 PubMed AA0017 RESID PSI-MOD slim (2S,3R)-2-amino-3-hydroxybutanoic acid alpha-amino-beta-hydroxybutyric acid beta-methylserine L-threo-threonine Thr DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 7 N 1 O 2 MassAvg 101.10 MassMono 101.047678 Origin T Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00027 L-tryptophan residue A protein modification that inserts or replaces a residue with an L-tryptophan residue. 29954 ChEBI 0 DeltaMass 2059637 PubMed 6692818 PubMed 9324768 PubMed AA0018 RESID PSI-MOD slim (S)-2-amino-3-(1H-indol-3-yl)propanoic acid alpha-amino-beta-(3-indolyl)propionoic acid beta-3-indolylalanine Trp DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 11 H 10 N 2 O 1 MassAvg 186.21 MassMono 186.079313 Origin W Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00028 L-tyrosine residue A protein modification that inserts or replaces a residue with an L-tyrosine residue. 29975 ChEBI 0 DeltaMass 2190093 PubMed 2542938 PubMed 5550972 PubMed 6061414 PubMed 6120171 PubMed 6692818 PubMed AA0019 RESID PSI-MOD slim (S)-2-amino-3-(4-hydoxyphenyl)propanoic acid alpha-amino-beta-(para-hydroxyphenyl)propionic acid p-tyrosine para-hydroxyphenylalanine Tyr DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 2 MassAvg 163.17 MassMono 163.063329 Origin Y Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00029 L-valine residue A protein modification that inserts or replaces a residue with an L-valine residue. 30015 ChEBI 0 DeltaMass 6692818 PubMed AA0020 RESID PSI-MOD slim (S)-2-amino-3-methylbutanoic acid alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid Val DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 MassAvg 99.13 MassMono 99.068414 Origin V Source Natural TermSpec none MOD:00009 PSI-MOD MOD:00030 N-formyl-L-methionine A protein modification that inserts or replaces a residue with an N-formyl-L-methionine residue, a natural pretranslational modification. 33718 ChEBI 10825024 PubMed 11152118 PubMed 2165784 PubMed 3042771 PubMed 8758896 PubMed AA0021 RESID 107 UniMod PSI-MOD slim (S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid Addition of N-formyl met fMet FormylMet N-formylated L-methionine N-formylmethionine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 6 H 10 N 1 O 2 S 1 MassAvg 160.21 MassMono 160.043224 Origin M Source Natural TermSpec N-term MOD:00409 MOD:00868 PSI-MOD MOD:00031 L-selenocysteine residue A protein modification that inserts or replaces a residue with an L-selenocysteine residue, a natural pretranslational modification. 30000 ChEBI 10523135 PubMed 1066676 PubMed 2037562 PubMed 2963330 PubMed 4734725 PubMed 6076213 PubMed 6217842 PubMed 6714945 PubMed AA0022 RESID PSI-MOD slim (R)-2-amino-3-selanylpropanoic acid 3-selenylalanine Sec SeCys selenium cysteine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 Se 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 Se 1 MassAvg 150.04 MassMono 150.953636 Origin U Source Natural TermSpec none MOD:00745 MOD:00859 MOD:00868 PSI-MOD MOD:00032 uncategorized protein modification A protein modification that is not chemically categorized. ref PSI-MOD MOD:00000 PSI-MOD MOD:00033 crosslinked residues A protein modification that crosslinks two or more residues with covalent bonds. ref PSI-MOD The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. PSI-MOD slim MOD:01156 PSI-MOD MOD:00034 L-cystine (cross-link) A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. 16283 ChEBI 0 DeltaMass 1988019 PubMed 2001356 PubMed 2076469 PubMed 3083866 PubMed 366603 PubMed 7918467 PubMed 8344916 PubMed AA0025 RESID Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. PSI-MOD slim (R,R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid [misnomer] 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide Cys2 Cysteine (covalent) Cystine ((Cys)2) dicysteine DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 S 2 MassAvg 204.27 MassMono 204.002719 Origin C, C Source Natural TermSpec none MOD:00689 MOD:00905 PSI-MOD MOD:00035 L-erythro-beta-hydroxyasparagine A protein modification that effectively converts an L-asparagine residue to L-erythro-beta-hydroxyasparagine. 11823643 PubMed 2820791 PubMed AA0026 RESID PSI-MOD slim (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid 3-hydroxyasparagine 3HyAsn erythro-beta-hydroxylated L-asparagine DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 6 N 2 O 3 MassAvg 130.10 MassMono 130.037842 Origin N Source Natural TermSpec none MOD:00425 MOD:00903 PSI-MOD MOD:00036 L-erythro-beta-hydroxyaspartic acid A protein modification that effectively converts an L-aspartic acid residue to L-erythro-beta-hydroxyaspartic acid. 6572939 PubMed 6871167 PubMed 8355279 PubMed AA0027 RESID PSI-MOD slim (2S,3R)-2-amino-3-hydroxybutanedioic acid 3-hydroxyaspartate 3HyAsp erythro-beta-hydroxylated L-aspartic acid DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 5 N 1 O 4 MassAvg 131.09 MassMono 131.021858 Origin D Source Natural TermSpec none MOD:00425 MOD:00904 PSI-MOD MOD:00037 5-hydroxy-L-lysine A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine. 18040 ChEBI 13375629 PubMed 15504407 PubMed 16101297 PubMed 2857489 PubMed AA0028 RESID PSI-MOD slim (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid 5-hydroxylated L-lysine 5-hydroxylysine 5HyLys alpha,epsilon-diamino-delta-hydroxycaproic acid L-erythro-delta-hydroxylysine DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source Natural TermSpec none MOD:01047 PSI-MOD MOD:00038 3-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. 16889 ChEBI 2400108 PubMed 3734192 PubMed 4343807 PubMed AA0029 RESID PSI-MOD slim (2S,3R)-3-hydroxy-2-pyrrolidinecarboxylic acid 3-hydroxylated L-proline 3-hydroxyproline 3-trans-hydroxy-L-proline 3HyPro beta-hydroxypyrrolidine-alpha-carboxylic acid L-threo-3-hydroxyproline DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.11 MassMono 113.047678 Origin P Source Natural TermSpec none MOD:01024 PSI-MOD MOD:00039 4-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline 18095 ChEBI 11292863 PubMed 2400108 PubMed 3734192 PubMed AA0030 RESID PSI-MOD slim (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid 4-hydroxylated L-proline 4-hydroxyproline 4-hydroxyproline 4-trans-hydroxy-L-proline 4HyPro gamma-hydroxypyrrolidine-alpha-carboxylic acid L-threo-4-hydroxyproline DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.11 MassMono 113.047678 Origin P Source Natural TermSpec none MOD:01024 PSI-MOD MOD:00040 2-pyrrolidone-5-carboxylic acid (Gln) A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. 30652 ChEBI 123 DeltaMass 10214721 PubMed 1836357 PubMed 26343 PubMed 3473473 PubMed AA0031 RESID 28 UniMod DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 PSI-MOD slim (S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid Gln->pyro-Glu N-pyrrolidone carboxyl (N terminus) PyrGlu(Gln) Pyro-glu from Q pyroglutamic acid Pyroglutamic Acid formed from Gln Pyroglutamyl Pyrrolidone carboxylic acid DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 5 H 6 N 1 O 2 MassAvg 112.11 MassMono 112.039853 Origin Q Source natural TermSpec N-term MOD:00601 MOD:00907 MOD:01160 PSI-MOD MOD:00041 L-gamma-carboxyglutamic acid A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. 217 DeltaMass 10517147 PubMed 1807167 PubMed 3263814 PubMed 4528109 PubMed 7457858 PubMed 8135347 PubMed 8868490 PubMed 9188685 PubMed AA0032 RESID 299 UniMod site DeltaMass has the formula C 6 H 7 N 5 O 1 with mass 173 PSI-MOD slim (S)-3-amino-1,1,3-propanetricarboxylic acid 1-carboxyglutamic acid [misnomer] 4-carboxyglutamate 4-carboxyglutamic acid 4CbxGlu Carboxy Carboxy Glutamyl Carboxylation gamma-carboxylated L-glutamic acid DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 6 H 7 N 1 O 5 MassAvg 173.12 MassMono 173.032422 Origin E Source Natural TermSpec none MOD:00906 MOD:01152 PSI-MOD MOD:00042 L-aspartic 4-phosphoric anhydride A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. 15836 ChEBI 4357737 PubMed AA0033 RESID 21 UniMod site PSI-MOD slim (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid 2-aminobutanedioic 4-phosphoric anhydride 4-aspartylphosphate 4-oxo-O-phosphono-L-homoserine 4-phosphoaspartic acid 4-phosphorylated L-aspartatic acid beta-aspartyl phosphate PhosAsp Phospho Phosphorylation DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 4 H 6 N 1 O 6 P 1 MassAvg 195.07 MassMono 194.993273 Origin D Source Natural TermSpec none MOD:00696 MOD:00904 PSI-MOD MOD:00043 S-phospho-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. 3142516 PubMed 7961745 PubMed 8128219 PubMed AA0034 RESID 21 UniMod site PSI-MOD slim (R)-2-amino-3-(phosphonosulfanyl)propanoic acid cysteine phosphate thioester PhosCys Phospho Phosphocysteine Phosphorylation S-phosphonocysteine S-phosphorylated L-cysteine S3-phosphocysteine DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 S 0 DiffMono 79.966330 Formula C 3 H 6 N 1 O 4 P 1 S 1 MassAvg 183.12 MassMono 182.975515 Origin C Source Natural TermSpec none MOD:00696 MOD:00777 MOD:00905 PSI-MOD MOD:00044 1'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (Ntau-phospho-L-histidine, 1'-phospho-L-histidine). 11038361 PubMed 5642389 PubMed 6692818 PubMed AA0035 RESID 21 UniMod site PSI-MOD slim (S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid histidine-3-phosphate [misnomer] histidine-N(epsilon)-phosphate histidine-N1'-phosphate N1-phosphonohistidine NE2-phosphonohistidine Ntau-phosphorylated L-histidine NtauPhosHis Phospho Phosphorylation tau-phosphohistidine tele-phosphohistidine DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 6 H 8 N 3 O 4 P 1 MassAvg 217.12 MassMono 217.025242 Origin H Source Natural TermSpec none MOD:00890 PSI-MOD MOD:00045 3'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (Npi-phospho-L-histidine, 3'-phospho-L-histidine). 1549615 PubMed 5642389 PubMed 6692818 PubMed 7669763 PubMed 7803390 PubMed AA0036 RESID 21 UniMod site PSI-MOD slim (S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid histidine-1-phosphate [misnomer] histidine-N(delta)-phosphate histidine-N3'-phosphate N3-phosphonohistidine ND1-phosphonohistidine Npi-phosphorylated L-histidine NpiPhosHis Phospho Phosphorylation pi-phosphohistidine Pros-phosphohistidine pros-phosphohistidine DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 6 H 8 N 3 O 4 P 1 MassAvg 217.12 MassMono 217.025242 Origin H Source Natural TermSpec none MOD:00890 PSI-MOD MOD:00046 O-phospho-L-serine A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. 15811 ChEBI 0 DeltaMass 12923550 PubMed 4065410 PubMed 8061611 PubMed AA0037 RESID 21 UniMod site PSI-MOD slim (S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine OPhosSer Phospho Phospho Seryl Phosphorylation Phosphoserine serine phosphate ester DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 3 H 6 N 1 O 5 P 1 MassAvg 167.06 MassMono 166.998359 Origin S Source Natural TermSpec none MOD:00696 MOD:00771 MOD:00916 PSI-MOD MOD:00047 O-phospho-L-threonine A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. 21967 ChEBI 0 DeltaMass 12923550 PubMed 7678926 PubMed AA0038 RESID 21 UniMod site PSI-MOD slim (2S,3R)-2-amino-3-phosphonooxybutanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate O-phosphorylated L-threonine O3-phosphothreonine OPhosThr Phospho Phospho Threonyl Phosphorylation Phosphothreonine threonine phosphate ester DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 4 H 8 N 1 O 5 P 1 MassAvg 181.08 MassMono 181.014009 Origin T Source Natural TermSpec none MOD:00696 MOD:00773 MOD:00917 PSI-MOD MOD:00048 O4'-phospho-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. 0 DeltaMass 10226369 PubMed 1725475 PubMed AA0039 RESID 21 UniMod site PSI-MOD slim (S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phosphorylated L-tyrosine O4-phosphotyrosine OPhosTyr Phospho Phospho Tyrosinyl Phosphorylation Phosphotyrosine tyrosine phosphate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966330 Formula C 9 H 10 N 1 O 5 P 1 MassAvg 243.15 MassMono 243.029659 Origin Y Source Natural TermSpec none MOD:00696 MOD:00774 MOD:00919 PSI-MOD MOD:00049 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine A protein modification that effectively converts an L-histidine residue to diphthamide. 16692 ChEBI 122 DeltaMass 15316019 PubMed 7430147 PubMed AA0040 RESID 375 UniMod PSI-MOD slim (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium Diphth Diphthamide diphthamide Diphthamide Diphthamide diphthamide (from histidine) DiffAvg 143.21 DiffFormula C 7 H 15 N 2 O 1 DiffMono 143.118438 Formula C 13 H 22 N 5 O 2 MassAvg 280.35 MassMono 280.177350 Origin H Source Natural TermSpec none MOD:00909 PSI-MOD MOD:00050 N-acetyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. 363452 PubMed 4700463 PubMed AA0041 RESID PSI-MOD slim (S)-2-(acetamido)propanoic acid 2-(acetylamino)propanoic acid AcAla acetylalanine N-acetylalanine N-acetylated L-alanine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 5 H 8 N 1 O 2 MassAvg 114.12 MassMono 114.055504 Origin A Source Natural TermSpec N-term MOD:00408 MOD:00901 PSI-MOD MOD:00051 N-acetyl-L-aspartic acid A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. 21547 ChEBI 1560020 PubMed 2395459 PubMed AA0042 RESID PSI-MOD slim (S)-2-(acetamido)butanedioic acid 2-(acetylamino)butanedioic acid AcAsp acetylaspartic acid N-acetylaspartate N-acetylated L-aspartic acid DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 8 N 1 O 4 MassAvg 158.13 MassMono 158.045333 Origin D Source Natural TermSpec N-term MOD:00408 MOD:00904 PSI-MOD MOD:00052 N-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. 28939 ChEBI 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 1500421 PubMed 15350136 PubMed 6725286 PubMed AA0043 RESID 1 UniMod site incidental to RESID:AA0223 PSI-MOD slim (R)-2-acetamido-3-sulfanylpropanoic acid 2-acetylamino-3-mercaptopropanoic acid 2-acetylamino-3-sulfanylpropanoic acid Acetyl Acetylation N-acetylated cysteine N-acetylcysteine N-acetylcysteine NAcCys DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 5 H 8 N 1 O 2 S 1 MassAvg 146.19 MassMono 146.027574 Origin C Source Natural TermSpec N-term MOD:00408 MOD:00646 PSI-MOD MOD:00053 N-acetyl-L-glutamic acid A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. 17533 ChEBI 6725286 PubMed AA0044 RESID PSI-MOD slim (S)-2-(acetamido)pentanedioic acid 2-(acetylamino)pentanedioic acid acetylglutamic acid AcGlu N-acetylated L-glutamic acid N-acetylglutamate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 10 N 1 O 4 MassAvg 172.16 MassMono 172.060983 Origin E Source Natural TermSpec N-term MOD:00408 MOD:00906 PSI-MOD MOD:00054 N-acetyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. AA0045 RESID PSI-MOD slim (S)-2-acetamido-5-pentanediamic acid 2-acetylamino-5-pentanediamic acid acetylglutamine AcGln N-acetylated L-glutamine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 11 N 2 O 3 MassAvg 171.17 MassMono 171.076967 Origin Q Source Artifact TermSpec N-term MOD:00408 MOD:00907 PSI-MOD MOD:00055 N-acetylglycine A protein modification that effectively converts a glycine residue to N-acetylglycine. 272676 PubMed 5545094 PubMed 6754709 PubMed AA0046 RESID PSI-MOD slim 2-(acetamido)ethanoic acid 2-(acetylamino)ethanoic acid aceturic acid AcGly N-acetylated glycine N-acetylglycine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 4 H 6 N 1 O 2 MassAvg 100.10 MassMono 100.039853 Origin G Source Natural TermSpec N-term MOD:00408 MOD:00908 PSI-MOD MOD:00056 N-acetyl-L-isoleucine A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. 8034631 PubMed AA0047 RESID This modification has not been observed to occur naturally. PSI-MOD slim (2S,3S)-2-acetamido-3-methylpentanoic acid 2-acetylamino-3-methylpentanoic acid acetylisoleucine AcIle N-acetylated L-isoleucine N-acetylisoleucine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 14 N 1 O 2 MassAvg 156.20 MassMono 156.102454 Origin I Source Artifact TermSpec N-term MOD:00408 MOD:00910 PSI-MOD MOD:00057 N2-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed AA0048 RESID 1 UniMod site This modification has not been observed to occur naturally. PSI-MOD slim (S)-2-acetamido-6-aminohexanoic acid 2-acetylamino-6-aminohexanoic acid Acetyl Acetylation N2-acetylated L-lysine N2-acetyllysine N2AcLys DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 15 N 2 O 2 MassAvg 171.22 MassMono 171.113353 Origin K Source Artifact TermSpec N-term MOD:00723 PSI-MOD MOD:00058 N-acetyl-L-methionine A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. 7944406 PubMed AA0049 RESID PSI-MOD slim (S)-2-acetamido-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylthio)butanoic acid acetylmethionine AcMet methionamine N-acetylated L-methionine N-acetylmethionine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 7 H 12 N 1 O 2 S 1 MassAvg 174.24 MassMono 174.058874 Origin M Source Natural TermSpec N-term MOD:00408 MOD:00913 PSI-MOD MOD:00059 N-acetyl-L-proline A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. 2928307 PubMed AA0050 RESID PSI-MOD slim (2S)-1-acetyl-2-pyrrolidinecarboxylic acid 1-acetylproline [misnomer] acetylproline AcPro N-acetylated L-proline N-acetylproline N-acetylproline DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 10 N 1 O 2 MassAvg 140.16 MassMono 140.071154 Origin P Source Natural TermSpec N-term MOD:00408 MOD:00915 PSI-MOD MOD:00060 N-acetyl-L-serine A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 1880797 PubMed 2106685 PubMed 6997045 PubMed AA0051 RESID 1 UniMod site PSI-MOD slim (S)-2-acetamido-3-hydroxypropanoic acid 2-acetylamino-3-hydroxypropanoic acid Acetyl Acetylation N-acetylated L-serine N-acetylserine N-acetylserine NAcSer DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 5 H 8 N 1 O 3 MassAvg 130.12 MassMono 130.050418 Origin S Source Natural TermSpec N-term MOD:00408 MOD:00647 PSI-MOD MOD:00061 N-acetyl-L-threonine A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 2106685 PubMed 6997045 PubMed AA0052 RESID 1 UniMod site PSI-MOD slim (2S,3R)-2-acetamido-3-hydroxybutanoic acid 2-acetylamino-3-hydroxybutanoic acid Acetyl Acetylation N-acetylated L-threonine N-acetylthreonine N-acetylthreonine NAcThr DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 10 N 1 O 3 MassAvg 144.15 MassMono 144.066068 Origin T Source Natural TermSpec N-term MOD:00408 MOD:01186 PSI-MOD MOD:00062 N-acetyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 2506074 PubMed 475783 PubMed AA0053 RESID 1 UniMod site PSI-MOD slim (S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid Acetyl Acetylation AcTyr N-acetylated L-tyrosine N-acetyltyrosine N-acetyltyrosine DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 11 H 12 N 1 O 3 MassAvg 206.22 MassMono 206.081718 Origin Y Source natural TermSpec N-term MOD:00408 MOD:00919 PSI-MOD MOD:00063 N-acetyl-L-valine A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. 1735421 PubMed AA0054 RESID PSI-MOD slim (S)-2-acetamido-3-methylbutanoic acid 2-acetylamino-3-methylbutanoic acid AcVal N-acetylated L-valine N-acetylvaline N-acetylvaline DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 12 N 1 O 2 MassAvg 142.18 MassMono 142.086804 Origin V Source Natural TermSpec N-term MOD:00408 MOD:00920 PSI-MOD MOD:00064 N6-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. 17752 ChEBI 214 DeltaMass 11369851 PubMed 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 1680872 PubMed 670159 PubMed AA0055 RESID 1 UniMod site PSI-MOD slim (S)-2-amino-6-acetamidohexanoic acid 2-amino-6-acetylaminohexanoic acid Acetyl Acetylation epsilon-acetyllysine N(zeta)-acetyllysine N6-acetylated L-lysine N6-acetyllysine N6AcLys DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 14 N 2 O 2 MassAvg 170.21 MassMono 170.105528 Origin K Source natural TermSpec none MOD:00723 PSI-MOD MOD:00065 S-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 1310545 PubMed 14730666 PubMed 15350136 PubMed AA0056 RESID 1 UniMod site PSI-MOD slim (R)-2-amino-3-(acetylsulfanyl)propanoic acid 2-amino-3-(acetylthio)propanoic acid Acetyl Acetylation cysteine acetate thioester S-acetylcysteine SAcCys DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 5 H 7 N 1 O 2 S 1 MassAvg 145.18 MassMono 145.019749 Origin C Source Natural TermSpec none MOD:00645 MOD:00646 PSI-MOD MOD:00066 N-formylglycine A protein modification that effectively converts a glycine residue to N-formylglycine. 5139483 PubMed AA0057 RESID PSI-MOD slim formylaminoethanoic acid N(alpha)-formylglycine N-formylated glycine N-formylglycine NFoGly DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin G Source Natural TermSpec N-term MOD:00409 MOD:00908 PSI-MOD MOD:00067 N-D-glucuronoyl-glycine modification from RESID 10858503 PubMed 12716131 PubMed 6493057 PubMed 7398618 PubMed AA0058 RESID 54 UniMod site PSI-MOD slim NGlcAGly DiffAvg 176.12 DiffFormula C 6 H 8 N 0 O 6 DiffMono 176.032088 Formula C 8 H 12 N 1 O 7 MassAvg 234.18 MassMono 234.061377 Origin G Source Natural TermSpec N-term MOD:00447 MOD:00908 PSI-MOD MOD:00068 N-myristoyl-glycine A protein modification that effectively converts a glycine residue to N-myristoylglycine. 11955007 PubMed 11955008 PubMed 1326520 PubMed 1386601 PubMed 6436247 PubMed 7543369 PubMed AA0059 RESID 45 UniMod site PSI-MOD slim (tetradecanoylamino)ethanoic acid Myristoyl Myristoylation N-(1-oxotetradecyl)glycine N-myristoyl glycine N-myristoylated glycine N-myristylglycine N-tetradecanoylglycine NMyrGly DiffAvg 210.36 DiffFormula C 14 H 26 N 0 O 1 DiffMono 210.198365 Formula C 16 H 30 N 1 O 2 MassAvg 268.41 MassMono 268.227654 Origin G Source Natural TermSpec N-term MOD:00650 MOD:00908 PSI-MOD MOD:00069 N-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. 10896212 PubMed 4575979 PubMed 9056182 PubMed 9593755 PubMed AA0060 RESID 47 UniMod site incidental to RESID:AA0107 incidental to RESID:AA0309 PSI-MOD slim (R)-2-hexadecanoylamino-3-sulfanylpropanoic acid 2-hexadecanoylamino-3-mercaptopropanoic acid N-(1-oxahexadecyl)-L-cysteine N-palmitoyl cysteine N-palmitoylated L-cysteine NPamCys Palmitoyl Palmitoylation DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 19 H 36 N 1 O 2 S 1 MassAvg 342.56 MassMono 342.246675 Origin C Source Natural TermSpec N-term MOD:00651 MOD:00905 PSI-MOD MOD:00070 N-methyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. 17519 ChEBI 323502 PubMed 337304 PubMed 7007074 PubMed AA0061 RESID PSI-MOD slim (S)-2-methylaminopropanoic acid N-methylalanine N-methylalanine N-methylated L-alanine NMeAla DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 4 H 7 N 1 O 1 MassAvg 85.10 MassMono 85.052764 Origin A Source Natural TermSpec none MOD:00599 MOD:00602 MOD:00665 PSI-MOD MOD:00071 N,N,N-trimethyl-L-alanine A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. 12590383 PubMed 332162 PubMed 3979397 PubMed 6778808 PubMed 7715456 PubMed AA0062 RESID 37 UniMod site PSI-MOD slim (S)-1-carboxy-N,N,N-trimethylethanaminium (S)-2-(trimethylammonio)propanoic acid N,N,N-trimethylalanine N,N,N-trimethylated L-alanine NMe3Ala tri-Methylation Trimethyl DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054775 Formula C 6 H 13 N 1 O 1 MassAvg 115.17 MassMono 115.099714 Origin A Source Natural TermSpec N-term MOD:00430 MOD:00602 MOD:00665 MOD:00711 PSI-MOD MOD:00072 N-methylglycine A protein modification that effectively converts an glycine residue to N-methylglycine. 15611 ChEBI 0 DeltaMass 1593629 PubMed AA0063 RESID DeltaMass also has an entry for the free amino acid PSI-MOD slim L-sarcosine methylaminoacetic acid methylaminoethanoic acid N-methylated glycine NMeGly Sar Sarcosine Sarcosyl DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin G Source Natural TermSpec none MOD:00570 MOD:00599 MOD:00602 MOD:00714 PSI-MOD MOD:00073 N-methyl-L-methionine A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. 169 DeltaMass 323502 PubMed 3298225 PubMed AA0064 RESID PSI-MOD slim (S)-2-methylamino-4-(methylsulfanyl)butanoic acid 2-methylamino-4-(methylthio)butanoic acid Methyl Methionyl N-methylated L-methionine N-methylmethionine N-methylmethionine NMeMet DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula C 6 H 11 N 1 O 1 S 1 MassAvg 145.22 MassMono 145.056135 Origin M Source Natural TermSpec none MOD:00599 MOD:00602 MOD:00716 PSI-MOD MOD:00074 N-methyl-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. 2577730 PubMed 413571 PubMed AA0065 RESID PSI-MOD slim (S)-2-methylamino-3-phenylpropanoic acid N-methylated L-phenylalanine N-methylphenylalanine N-methylphenylalanine NMePhe DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 10 H 11 N 1 O 1 MassAvg 161.20 MassMono 161.084064 Origin F Source Natural TermSpec none MOD:00599 MOD:00602 MOD:00717 PSI-MOD MOD:00075 N,N-dimethyl-L-proline A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. 21451 ChEBI 12964758 PubMed 14570711 PubMed 193025 PubMed 3882426 PubMed 6254758 PubMed AA0066 RESID 36 UniMod site PSI-MOD slim (S)-2-carboxy-1,1-dimethylpyrrolidinium (S)-2-carboxy-1,1-dimethylpyrrolidinium 1,1-dimethyl-L-prolinium [misnomer] di-Methylation Dimethyl N,N-dimethyl-L-prolinium N,N-dimethylated L-proline N,N-dimethylproline NMe2Pro stachydrin DiffAvg 29.06 DiffFormula C 2 H 5 N 0 O 0 DiffMono 29.039125 Formula C 7 H 13 N 1 O 1 MassAvg 127.18 MassMono 127.099714 Origin X TermSpec N-term MOD:00602 MOD:00710 MOD:00712 PSI-MOD MOD:00076 omega-N,omega-N'-dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega),N'(omega)-dimethyl-L-arginine. 12964758 PubMed 14570711 PubMed 15835918 PubMed 2426402 PubMed 5128665 PubMed AA0067 RESID 36 UniMod site PSI-MOD slim (S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid di-Methylation Dimethyl N3,N4-dimethylarginine N5-[(methylamino)(methylimino)methyl]ornithine NG,N'G-dimethylarginine NoNo'Me2Arg omega-N,omega-N'-dimethylated L-arginine Symmetric dimethylarginine symmetric dimethylarginine DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 4 O 1 MassAvg 184.24 MassMono 184.132411 Origin R Source Natural TermSpec none MOD:00602 MOD:00783 PSI-MOD MOD:00077 omega-N,omega-N-dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega),N(omega)-dimethyl-L-arginine. 17929 ChEBI 11152131 PubMed 12964758 PubMed 14570711 PubMed 15835918 PubMed 3032834 PubMed AA0068 RESID 36 UniMod site PSI-MOD slim (S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid Asymmetric dimethylarginine asymmetric dimethylarginine di-Methylation Dimethyl N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine NoNoMe2Arg omega-N,omega-N-dimethlyated L-arginine DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 4 O 1 MassAvg 184.24 MassMono 184.132411 Origin R Source Natural TermSpec none MOD:00602 MOD:00783 PSI-MOD MOD:00078 omega-N-methyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. 11875433 PubMed 15835918 PubMed 2426402 PubMed 5128665 PubMed AA0069 RESID 34 UniMod site PSI-MOD slim (S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid Methyl Methylation NG-methylarginine NoMeArg Omega-N-methylarginine omega-N-methylated L-arginine DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 4 O 1 MassAvg 170.21 MassMono 170.116761 Origin R Source Natural TermSpec none MOD:00414 MOD:00602 PSI-MOD MOD:00079 N4-methyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. 11875433 PubMed 2356973 PubMed 3782095 PubMed AA0070 RESID 34 UniMod site PSI-MOD slim (S)-2-amino-N4-methylbutanediamic acid beta-methylasparagine [misnomer] Methyl Methylation N(gamma)-methylasparagine N-methylasparagine N4-methylasparagine N4-methylated L-asparagine N4MeAsn DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 8 N 2 O 2 MassAvg 128.13 MassMono 128.058578 Origin N Source Natural TermSpec none MOD:00599 MOD:00602 MOD:00673 MOD:00894 PSI-MOD MOD:00080 N5-methyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. 17592 ChEBI 11118225 PubMed 11875433 PubMed 365579 PubMed AA0071 RESID 34 UniMod site PSI-MOD slim (2S)-2-amino-5-methylamino-5-oxopentanoic acid 2-amino-N5-methylpentanediamic acid gamma-methylglutamine Methyl Methylation N(delta)-methylglutamine N-methylglutamine N5-methylated L-glutamine N5-methylglutamine N5MeGln DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 2 O 2 MassAvg 142.16 MassMono 142.074228 Origin Q Source Natural TermSpec none MOD:00602 MOD:00722 PSI-MOD MOD:00081 L-glutamic acid 5-methyl ester A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. 167 DeltaMass 16888 PubMed 6300110 PubMed AA0072 RESID resulting DeltaMass gives the formula C 6 H 9 O 1 N 3 with mass 143. 5-methyl esterified L-glutamic acid Glutamate methyl ester (Glu) O-methyl Glutamyl O5MeGlu DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin E Source Natural TermSpec none MOD:00393 MOD:00599 MOD:00713 PSI-MOD MOD:00082 3'-methyl-L-histidine A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine. 10660523 PubMed 11875433 PubMed 3467365 PubMed 6692818 PubMed 8076 PubMed 8645219 PubMed AA0073 RESID 34 UniMod site PSI-MOD slim (S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid 1-methylhistidine [misnomer] Methyl Methylation N(delta)-methylhistidine NprosMeHis pi-methylhistidine pros-methylated L-histidine Pros-methylhistidine pros-methylhistidine DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 9 N 3 O 1 MassAvg 151.17 MassMono 151.074562 Origin H Source Natural TermSpec none MOD:00602 MOD:00724 PSI-MOD MOD:00083 N6,N6,N6-trimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. 17311 ChEBI 0 DeltaMass 12590383 PubMed 3145979 PubMed 4304194 PubMed 6778808 PubMed 7093227 PubMed 8453381 PubMed AA0074 RESID 37 UniMod site DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine PSI-MOD slim (S)-2-amino-6-(trimethylammonio)hexanoic acid (S)-5-amino-5-carboxy-N,N,N-trimethyl-1-pentanaminium epsilon-trimethyllysine N(zeta)-trimethyllysine N-trimethylation (of lysine) N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine N6Me3Lys tri-Methylation Trimethyl DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054775 Formula C 9 H 19 N 2 O 1 MassAvg 171.26 MassMono 171.149738 Origin K Source Natural TermSpec none MOD:00430 MOD:00602 MOD:00663 MOD:00711 PSI-MOD MOD:00084 N6,N6-dimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. 10550045 PubMed 12964758 PubMed 14570711 PubMed 3100523 PubMed 8453381 PubMed AA0075 RESID 36 UniMod site PSI-MOD slim (S)-2-amino-6-dimethylaminohexanoic acid di-Methylation Dimethyl epsilon-dimethyllysine lysine derivative Lys(y) N(zeta)-dimethyllysine N6,N6-dimethylated L-lysine N6,N6-dimethyllysine N6Me2Lys DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 2 O 1 MassAvg 156.23 MassMono 156.126263 Origin K Source Natural TermSpec none MOD:00429 MOD:00602 MOD:00663 PSI-MOD MOD:00085 N6-methyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. 17604 ChEBI 165 DeltaMass 11875433 PubMed 3926756 PubMed AA0076 RESID 34 UniMod site PSI-MOD slim (S)-2-amino-6-methylaminohexanoic acid epsilon-methyllysine Methyl Methylation N(zeta)-methyllysine N-methyl Lysyl N6-methylated L-lysine N6-methyllysine N6MeLys DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 2 O 1 MassAvg 142.20 MassMono 142.110613 Origin K Source Natural TermSpec none MOD:00599 MOD:00602 MOD:00663 PSI-MOD MOD:00086 N6-palmitoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. 2498336 PubMed 7801126 PubMed 7939682 PubMed AA0077 RESID 47 UniMod site PSI-MOD slim (S)-2-amino-6-(hexadecanoylamino)hexanoic acid epsilon-palmitoyllysine N(zeta)-palmitoyllysine N6-(1-oxohexadecyl)-L-lysine N6-palmitoyl lysine N6-palmitoylated L-lysine N6PamLys Palmitoyl Palmitoylation DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 22 H 42 N 2 O 2 MassAvg 366.58 MassMono 366.324629 Origin K Source Natural TermSpec none MOD:00651 MOD:00912 PSI-MOD MOD:00087 N6-myristoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. 1402651 PubMed 8346241 PubMed AA0078 RESID 45 UniMod site PSI-MOD slim (S)-2-amino-6-(tetradecanoylamino)hexanoic acid epsilon-myristoyllysine Myristoyl Myristoylation N(zeta)-myristoyllysine N6-(1-oxotetradecyl)-L-lysine N6-myristoyl lysine N6-myristoylated L-lysine N6MyrLys DiffAvg 210.36 DiffFormula C 14 H 26 N 0 O 1 DiffMono 210.198365 Formula C 20 H 38 N 2 O 2 MassAvg 338.53 MassMono 338.293328 Origin K Source Natural TermSpec none MOD:00650 MOD:00912 PSI-MOD MOD:00088 O-palmitoyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. 6642431 PubMed 8413602 PubMed AA0079 RESID 47 UniMod site PSI-MOD slim (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid L-threonine hexadecanoate ester O-palmitoyl threonine O-palmitoylated L-threonine O3-palmitoyl-threonine OPamThr Palmitoyl Palmitoylation threonine palmitate ester DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 20 H 37 N 1 O 3 MassAvg 339.51 MassMono 339.277344 Origin T Source Natural TermSpec none MOD:00652 MOD:00917 PSI-MOD MOD:00089 O-palmitoyl-L-serine A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. 3467339 PubMed AA0080 RESID 47 UniMod site PSI-MOD slim (2S,3R)-2-amino-3-(hexadecanoyloxy)propanoic acid L-serine hexadecanoate ester O-palmitoyl serine O-palmitoylated L-serine O3-palmitoyl-serine OPamSer Palmitoyl Palmitoylation serine palmitate ester DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 19 H 35 N 1 O 3 MassAvg 325.49 MassMono 325.261694 Origin S Source Natural TermSpec none MOD:00652 MOD:00916 PSI-MOD MOD:00090 L-alanine amide A protein modification that effectively converts an L-alanine residue to L-alanine amide. 1377792 PubMed 2069951 PubMed 8472537 PubMed 952951 PubMed AA0081 RESID PSI-MOD slim (S)-2-aminopropanamide AlaN alaninamide Alanine amide amidated L-alanine DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 3 H 7 N 2 O 1 MassAvg 87.10 MassMono 87.055838 Origin A Source Natural TermSpec C-term MOD:00883 MOD:00901 PSI-MOD MOD:00091 L-arginine amide A protein modification that effectively converts an L-arginine residue to L-arginine amide. 2229025 PubMed 2753890 PubMed 743209 PubMed AA0082 RESID PSI-MOD slim (S)-2-amino-5-carbamimidamidopentanamide 2-amino-5-guanidinopentanamide amidated L-arginine argininamide Arginine amide ArgN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 14 N 5 O 1 MassAvg 172.21 MassMono 172.119835 Origin R Source Natural TermSpec C-term MOD:00883 MOD:00902 PSI-MOD MOD:00092 L-asparagine amide A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. 2753132 PubMed 279902 PubMed 3415690 PubMed AA0083 RESID PSI-MOD slim (S)-2-amino-butanediamide amidated L-asparagine AsnN asparaginamide Asparagine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 8 N 3 O 2 MassAvg 130.13 MassMono 130.061652 Origin N Source Natural TermSpec C-term MOD:00883 MOD:00903 PSI-MOD MOD:00093 L-aspartic acid 1-amide A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. 2542051 PubMed AA0084 RESID PSI-MOD slim (S)-2-amino-1-butanediamic acid 1-amidated L-aspartic acid 3,4-diamino-4-oxabutanoic acid Aspartic acid 1-amide AspN isoasparagine DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 7 N 2 O 3 MassAvg 131.11 MassMono 131.045667 Origin D Source Natural TermSpec C-term MOD:00883 MOD:00904 PSI-MOD MOD:00094 L-cysteine amide A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. 1892838 PubMed 7149738 PubMed AA0085 RESID PSI-MOD slim (R)-2-amino-3-sulfanylpropanamide 2-amino-3-mercaptopropanamide amidated L-cysteine CysN cysteinamide Cysteine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 S 0 DiffMono -0.984016 Formula C 3 H 7 N 2 O 1 S 1 MassAvg 119.17 MassMono 119.027909 Origin C Source Natural TermSpec C-term MOD:00883 MOD:00905 PSI-MOD MOD:00095 L-glutamine amide A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. 7673220 PubMed 9048550 PubMed AA0086 RESID PSI-MOD slim (S)-2-amino-pentanediamide amidated L-glutamine GlnN glutaminamide Glutamine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 10 N 3 O 2 MassAvg 144.15 MassMono 144.077302 Origin Q Source Natural TermSpec C-term MOD:00883 MOD:00907 PSI-MOD MOD:00096 L-glutamic acid 1-amide A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. 1093875 PubMed 14550575 PubMed AA0087 RESID PSI-MOD slim (S)-2-amino-1-pentanediamic acid 1-amidated L-glutamic acid 4,5-diamino-5-oxapentanoic acid GluN Glutamic acid 1-amide isoglutamine DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 9 N 2 O 3 MassAvg 145.14 MassMono 145.061317 Origin E Source Natural TermSpec C-term MOD:00883 MOD:00906 PSI-MOD MOD:00097 glycine amide A protein modification that effectively converts a glycine residue to glycine amide. 13591312 PubMed AA0088 RESID PSI-MOD slim 2-aminoacetamide 2-aminoethanamide amidated glycine Glycine amide GlyN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 2 H 5 N 2 O 1 MassAvg 73.07 MassMono 73.040188 Origin G Source Natural TermSpec C-term MOD:00883 MOD:00908 PSI-MOD MOD:00098 L-histidine amide A protein modification that effectively converts an L-histidine residue to L-histidine amide. 2153586 PubMed 2307683 PubMed 2839478 PubMed AA0089 RESID PSI-MOD slim (S)-2-amino-3-(1H-imidazol-4-yl)propanamide amidated L-histidine HisN histidinamide Histidine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 9 N 4 O 1 MassAvg 153.16 MassMono 153.077636 Origin H Source Natural TermSpec C-term MOD:00883 MOD:00909 PSI-MOD MOD:00099 L-isoleucine amide A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. AA0090 RESID PSI-MOD slim (2S,3S)-2-amino-3-methylpentanamide amidated L-isoleucine IleN isoleucinamide Isoleucine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 13 N 2 O 1 MassAvg 129.18 MassMono 129.102788 Origin I Source Natural TermSpec C-term MOD:00883 MOD:00910 PSI-MOD MOD:00100 L-leucine amide A protein modification that effectively converts an L-leucine residue to L-leucine amide. 2578459 PubMed AA0091 RESID PSI-MOD slim (S)-2-amino-4-methylpentanamide amidated L-leucine leucinamide Leucine amide LeuN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 13 N 2 O 1 MassAvg 129.18 MassMono 129.102788 Origin L Source Natural TermSpec C-term MOD:00883 MOD:00911 PSI-MOD MOD:00101 L-lysine amide A protein modification that effectively converts an L-lysine residue to L-lysine amide. 6579533 PubMed AA0092 RESID PSI-MOD slim (S)-2,6-diaminohexanamide amidated L-lysine lysinamide Lysine amide LysN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 14 N 3 O 1 MassAvg 144.19 MassMono 144.113687 Origin K Source Natural TermSpec C-term MOD:00883 MOD:00912 PSI-MOD MOD:00102 L-methionine amide A protein modification that effectively converts an L-methionine residue to L-methionine amide. 4375977 PubMed AA0093 RESID PSI-MOD slim (S)-2-amino-4-(methylsulfanyl)butanamide 2-amino-4-(methylthio)butanamide amidated L-methionine methioninamide Methionine amide MetN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 S 0 DiffMono -0.984016 Formula C 5 H 11 N 2 O 1 S 1 MassAvg 147.22 MassMono 147.059209 Origin M Source Natural TermSpec C-term MOD:00883 MOD:00913 PSI-MOD MOD:00103 L-phenylalanine amide A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. 2905621 PubMed 8868490 PubMed AA0094 RESID PSI-MOD slim (S)-2-amino-3-phenylpropanamide amidated L-phenylalanine PheN phenylalaninamide Phenylalanine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 9 H 11 N 2 O 1 MassAvg 163.20 MassMono 163.087138 Origin F Source Natural TermSpec C-term MOD:00883 MOD:00914 PSI-MOD MOD:00104 L-proline amide A protein modification that effectively converts an L-proline residue to L-proline amide. 4982117 PubMed 5760861 PubMed AA0095 RESID PSI-MOD slim (S)-pyrrolidine-2-carboxamide amidated L-proline prolinamide Proline amide ProN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 9 N 2 O 1 MassAvg 113.14 MassMono 113.071488 Origin P Source Natural TermSpec C-term MOD:00883 MOD:00915 PSI-MOD MOD:00105 L-serine amide A protein modification that effectively converts an L-serine residue to L-serine amide. 743209 PubMed AA0096 RESID PSI-MOD slim (S)-2-amino-3-hydroxypropanamide amidated L-serine serinamide Serine amide SerN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 3 H 7 N 2 O 2 MassAvg 103.10 MassMono 103.050752 Origin S Source Natural TermSpec C-term MOD:00883 MOD:00916 PSI-MOD MOD:00106 L-threonine amide A protein modification that effectively converts an L-threonine residue to L-threonine amide. 1390774 PubMed AA0097 RESID PSI-MOD slim (2S,3R)-2-amino-3-hydroxybutanamide amidated L-threonine threoninamide Threonine amide ThrN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 9 N 2 O 2 MassAvg 117.13 MassMono 117.066403 Origin T Source Natural TermSpec C-term MOD:00883 MOD:00917 PSI-MOD MOD:00107 L-tryptophan amide A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. 3947348 PubMed AA0098 RESID PSI-MOD slim (S)-2-amino-3-(1H-indol-3-yl)propanamide amidated L-tryptophan TrpN Tryptophan amide tryptophanamide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 11 H 12 N 3 O 1 MassAvg 202.23 MassMono 202.098037 Origin W Source Natural TermSpec C-term MOD:00883 MOD:00918 PSI-MOD MOD:00108 L-tyrosine amide A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. 1377792 PubMed 3562898 PubMed 6509012 PubMed AA0099 RESID PSI-MOD slim (S)-2-amino-3-(4-hydoxyphenyl)propanamide amidated L-tyrosine TyrN tyrosinamide Tyrosine amide DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 9 H 11 N 2 O 2 MassAvg 179.20 MassMono 179.082053 Origin Y Source Natural TermSpec C-term MOD:00883 MOD:00919 PSI-MOD MOD:00109 L-valine amide A protein modification that effectively converts an L-valine residue to L-valine amide. 2578459 PubMed 5465996 PubMed AA0100 RESID PSI-MOD slim (S)-2-amino-3-methylbutanamide valinamide Valine amide ValN DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 11 N 2 O 1 MassAvg 115.15 MassMono 115.087138 Origin V Source Natural TermSpec C-term MOD:00883 MOD:00920 PSI-MOD MOD:00110 L-cysteine methyl disulfide modification from RESID 10555576 PubMed 2056535 PubMed 6381494 PubMed AA0101 RESID 39 UniMod site PSI-MOD slim (R)-2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldithio)propanoic acid Beta-methylthiolation Cysteine methyl disulfide L-3-(methyldithio)alanine Methylthio S-methyl thiocysteine DiffAvg 46.09 DiffFormula C 1 H 2 N 0 O 0 S 1 DiffMono 45.987721 Formula C 4 H 7 N 1 O 1 S 2 MassAvg 149.23 MassMono 148.996905 Origin C Source hypothetical TermSpec none MOD:00905 MOD:01153 PSI-MOD MOD:00111 S-farnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. 293 DeltaMass 1409665 PubMed 15609361 PubMed 1872463 PubMed 2684976 PubMed AA0102 RESID 44 UniMod site PSI-MOD slim (R,E,E)-2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylsulfanyl)propanoic acid 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid Farnesyl Farnesylation S-farnesyl cysteine S-farnesyl Cystenyl SFarnCys DiffAvg 204.35 DiffFormula C 15 H 24 N 0 O 0 S 0 DiffMono 204.187801 Formula C 18 H 29 N 1 O 1 S 1 MassAvg 307.49 MassMono 307.196985 Origin C Source Natural TermSpec none MOD:00437 MOD:00905 PSI-MOD MOD:00112 S-12-hydroxyfarnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. AA0103 RESID 376 UniMod PSI-MOD slim (R,E,E,Z)-2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylsulfanyl)propanoic acid 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid Hydroxyfarnesyl hydroxyfarnesyl S-12-hydroxyfarnesyl cysteine S12HyFarnCys DiffAvg 220.35 DiffFormula C 15 H 24 N 0 O 1 S 0 DiffMono 220.182715 Formula C 18 H 29 N 1 O 2 S 1 MassAvg 323.49 MassMono 323.191900 Origin C Source Natural TermSpec none MOD:00703 MOD:00905 PSI-MOD MOD:00113 S-geranylgeranyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. 0 DeltaMass 1483450 PubMed 15609361 PubMed AA0104 RESID 48 UniMod site DeltaMass calculates the mass with two double bonds rather than four PSI-MOD slim (R,E,E,E)-2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylsulfanyl)propanoic acid 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid Geranyl-geranyl GeranylGeranyl S-geranylgeranyl S-geranylgeranyl cysteine SGergerCys DiffAvg 272.47 DiffFormula C 20 H 32 N 0 O 0 S 0 DiffMono 272.250401 Formula C 23 H 37 N 1 O 1 S 1 MassAvg 375.61 MassMono 375.259586 Origin C Source Natural TermSpec none MOD:00441 MOD:00905 PSI-MOD MOD:00114 L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. 11875433 PubMed 1872463 PubMed AA0105 RESID 34 UniMod site Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. PSI-MOD slim 2-amino-3-mercaptopropanoic methyl ester 2-amino-3-sulfanylpropanoic methyl ester Cysteine methyl ester mecysteine Methyl methyl (2R)-2-amino-3-sulfanylpropanoate methyl esterified L-cysteine methyl L-cysteinate Methylation OMeCys DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula C 4 H 8 N 1 O 2 S 1 MassAvg 134.18 MassMono 134.027574 Origin X TermSpec C-term MOD:00393 MOD:00599 MOD:00660 PSI-MOD MOD:00115 S-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. 303 DeltaMass 1872406 PubMed 3166978 PubMed 8180229 PubMed 8824274 PubMed AA0106 RESID 47 UniMod site PSI-MOD slim (R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid 2-amino-3-(hexadecanoylthio)propanoic acid cysteine hexadecanoate thioester cysteine palmitate thioester Palmitoyl Palmitoylation S-palmitoyl cysteine S-palmitoylated L-cysteine S-palmityl Cystenyl SPamCys DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 19 H 35 N 1 O 2 S 1 MassAvg 341.55 MassMono 341.238850 Origin C Source Natural TermSpec none MOD:00653 MOD:00905 PSI-MOD MOD:00116 S-diacylglycerol-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. 10896212 PubMed 4575979 PubMed 9056182 PubMed AA0107 RESID 377 UniMod Incidental to RESID:AA0060. PSI-MOD slim (R)-2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid Diacylglycerol diacylglycerol S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine S-(2',3'-diacylglycerol)-L-cysteine S-diacylglycerol cysteine Origin C Source Natural TermSpec none MOD:00905 MOD:01155 PSI-MOD MOD:00117 S-(L-isoglutamyl)-L-cysteine A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond to form S-(L-isoglutamyl)-L-cysteine. 22021 ChEBI 0 DeltaMass 6838833 PubMed AA0108 RESID Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. PSI-MOD slim (S)-2-amino-5-((R)-2-amino-2-carboxyethyl)sulfanyl-5-oxopentanoic acid (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid gamma-(S-cysteinyl)glutamic acid Isoglutamyl cysteine thioester (Cys-Gln) S-gamma-glutamyl (crosslinked to cysteine) DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 S 0 DiffMono -17.026549 Formula C 8 H 10 N 2 O 3 S 1 MassAvg 214.24 MassMono 214.041213 Origin C, Q Source Natural TermSpec none MOD:00395 MOD:00905 MOD:00907 MOD:00946 PSI-MOD MOD:00118 2'-(S-L-cysteinyl)-L-histidine A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. 0 DeltaMass 6210696 PubMed AA0109 RESID Cross-link 2. PSI-MOD slim (S)-2-amino-3-[2-((R)-2-amino-2-carboxyethyl)sulfanylimidazol-4-yl]propanoic acid 2'-(S-cysteinyl)-histidine (Cys-His) S-(2'-histidyl)cysteine S-(2-histidyl)- (crosslinked to cysteine) DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 9 H 10 N 4 O 2 S 1 MassAvg 238.27 MassMono 238.052446 Origin C, H Source Natural TermSpec none MOD:00687 MOD:00905 MOD:00909 PSI-MOD MOD:00119 L-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. 21347 ChEBI 7 DeltaMass AA0110 RESID Cross-link 2. PSI-MOD slim (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfanediyl (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030648 Origin C, S Source Artifact TermSpec none MOD:00687 MOD:00905 MOD:00916 MOD:00954 PSI-MOD MOD:00120 meso-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. 15023056 PubMed 3769923 PubMed AA0111 RESID Cross-link 2. This modification has not been observed to occur naturally. PSI-MOD slim (R)-S-(2-amino-2-carboxyethyl)-D-cysteine (R,S)-2,6-diamino-4-thiaheptanedioic acid (R,S)-3,3'-thiobis-(2-aminopropanoic acid) (R,S)-bis(2-amino-2-carboxyethyl)sulfanediyl (R,S)-bis(2-amino-2-carboxyethyl)sulfide 3,3'-thiobis-meso-alanine cysteine-3-D-alanine thioether Lanthionine (Ser-Cys) DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030648 Origin C, S Source natural TermSpec none MOD:00687 MOD:00905 MOD:00916 MOD:00954 PSI-MOD MOD:00121 3-methyl-L-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyl-L-lanthionine. 3769923 PubMed AA0112 RESID Cross-link 2. PSI-MOD slim (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid Beta-methyllanthionine (Thr-Cys) cysteine-3-D-butyrine thioether DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 10 N 2 O 2 S 1 MassAvg 186.23 MassMono 186.046298 Origin C, T Source Natural TermSpec none MOD:00687 MOD:00905 MOD:00917 MOD:00954 PSI-MOD MOD:00122 3'-(S-L-cysteinyl)-L-tyrosine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. 0 DeltaMass 15917234 PubMed 2002850 PubMed AA0113 RESID Cross-link 2. PSI-MOD slim (S,R)-2-amino-3-[3-(2-amino-2-carboxyethylsulfanyl)-4-hydroxyphenyl]propanoic acid 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) S-(3'-tyrosinyl)cysteine S-(3-Tyr) (Crosslinked to Cysteine) XLNKSCys3'Tyr DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 3 S 1 MassAvg 264.30 MassMono 264.056863 Origin C, Y Source Natural TermSpec none MOD:00687 MOD:00905 MOD:00919 PSI-MOD MOD:00123 N6-carboxy-L-lysine modification from RESID 11369851 PubMed 4436319 PubMed 637859 PubMed 7754395 PubMed AA0114 RESID 299 UniMod site PSI-MOD slim (S)-2-amino-6-(carboxyamino)hexanoic acid 2-amino-6-carbamic hexanoic acid Carboxy Carboxylation lysine NZ-carboxylic acid N6-carbamyllysine [misnomer] N6-carboxylysine N6-carboxylysine N6CbxLys DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 7 H 12 N 2 O 3 MassAvg 172.18 MassMono 172.084792 Origin K Source Natural TermSpec none MOD:00912 MOD:01152 PSI-MOD MOD:00124 N6-1-carboxyethyl-L-lysine modification from RESID 3123486 PubMed 8253186 PubMed 8421682 PubMed AA0115 RESID 378 UniMod PSI-MOD slim (S,S)-2-amino-6-(1-carboxyethyl)aminohexanoic acid Carboxyethyl carboxyethyl N6-(1-carboxyethyl)lysine N6-1-carboxyethyl lysine NZ-(1-carboxyethyl)lysine DiffAvg 72.06 DiffFormula C 3 H 4 N 0 O 2 DiffMono 72.021129 Formula C 9 H 16 N 2 O 3 MassAvg 200.23 MassMono 200.116092 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00125 N6-(4-amino-2-hydroxybutyl)-L-lysine modification from RESID 0 DeltaMass 6806267 PubMed 8108861 PubMed AA0116 RESID 379 UniMod From DeltaMass: Average Mass: 87 PSI-MOD slim (S,R)-2-amino-6-(4-amino-2-hydroxybutylamino)hexanoic acid Hypu Hypusine hypusine Hypusine hypusine N-(4-NH2-2-OH-butyl)- (of Lysine) DiffAvg 87.12 DiffFormula C 4 H 9 N 1 O 1 DiffMono 87.068414 Formula C 10 H 21 N 3 O 2 MassAvg 215.29 MassMono 215.163377 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00126 N6-biotinyl-L-lysine modification from RESID 305 DeltaMass 16109483 PubMed 3178228 PubMed 7948875 PubMed 8747466 PubMed AA0117 RESID 3 UniMod From DeltaMass: Average Mass: 354 Formula:C16H26O4N3S1 Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex PSI-MOD slim (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine (S)-2-amino-6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]aminohexanoic acid biocytin Biotin Biotin (covalent) biotinyl lysyl Biotinylation epsilon-N-biotinyllysine N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine N6-biotinyllysine DiffAvg 226.30 DiffFormula C 10 H 14 N 2 O 2 S 1 DiffMono 226.077598 Formula C 16 H 26 N 4 O 3 S 1 MassAvg 354.47 MassMono 354.172561 Origin X TermSpec none MOD:00912 PSI-MOD MOD:00127 N6-lipoyl-L-lysine modification from RESID 0 DeltaMass 3421911 PubMed 3522581 PubMed 7719855 PubMed AA0118 RESID 42 UniMod From DeltaMass: Average Mass: 188 PSI-MOD slim (2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid (S)-2-amino-6-[5-((R)-1,2-dithiolan-3-yl)pentanamido]hexanoic acid 2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid Lipoyl Lipoyl Lipoyl (covalent) N-Lipoyl- (on Lysine) N6-6,8-dithiooctanoyllysine N6-lipoyllysine DiffAvg 188.31 DiffFormula C 8 H 12 N 0 O 1 S 2 DiffMono 188.032956 Formula C 14 H 24 N 2 O 2 S 2 MassAvg 316.48 MassMono 316.127919 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00128 N6-pyridoxal phosphate-L-lysine modification from RESID 0 DeltaMass 1544460 PubMed AA0119 RESID 46 UniMod From DeltaMass: Average Mass: 231 PSI-MOD slim (S)-2-amino-6-[(3-hydroxy-2-methyl-5-phosphonooxymethyl-4-pyridine)methyleneamino]hexanoic acid Pyridoxal phosphate Pyridoxal phosphate (covalent) Pyridoxal phosphate (Schiff Base formed to lysine) PyridoxalPhosphate DiffAvg 229.13 DiffFormula C 8 H 8 N 1 O 5 P 1 DiffMono 229.014009 Formula C 14 H 20 N 3 O 6 P 1 MassAvg 357.30 MassMono 357.108972 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00129 N6-retinylidene-L-lysine modification from RESID 6794028 PubMed 6870827 PubMed AA0120 RESID 380 UniMod PSI-MOD slim (S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid N6-retinal-L-lysine N6-retinyl-lysine retinal Retinal chromophore (covalent) Retinylidene DiffAvg 266.42 DiffFormula C 20 H 26 N 0 O 0 DiffMono 266.203451 Formula C 26 H 38 N 2 O 1 MassAvg 394.59 MassMono 394.298414 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00130 L-allysine modification from UniMod and RESID 17917 ChEBI 0 DeltaMass 11120890 PubMed 11332453 PubMed 358196 PubMed 5337886 PubMed 5529814 PubMed 9252331 PubMed AA0121 RESID 352 UniMod site From DeltaMass: Average Mass: -1 PSI-MOD slim (S)-2-amino-6-oxohexanoic acid 2-amino-5-formylvaleric acid 2-amino-adipic acid semialdahyde 2-aminoadipate 6-semialdehyde 5-formyl-norvaline 6-oxonorleucine Allysine Allysine (from Lysine) alpha-amino-adipic acid delta-semialdahyde Lys->Allysine Lysine oxidation to aminoadipic semialdehyde Oxidation of lysine (to aminoadipic semialdehyde) DiffAvg -1.03 DiffFormula C 0 H -3 N -1 O 1 DiffMono -1.031634 Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00131 L-2-aminoadipic acid modification from RESID 353 DeltaMass 336041 PubMed 358196 PubMed 7419498 PubMed AA0122 RESID 381 UniMod From DeltaMass: Average Mass: 15 Monoisotopic Mass Change:14.97 Average Mass Change:15 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. PSI-MOD slim (S)-2-aminohexanedioic acid 2-amino-1,4-butanedicarboxylic acid alpha-amino adipic acid L-alpha-aminoadipic acid Lys->AminoadipicAcid Oxidation of lysine (to aminoadipic acid) DiffAvg 14.97 DiffFormula C 0 H -3 N -1 O 2 DiffMono 14.963280 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin K Source Natural TermSpec none MOD:00912 PSI-MOD MOD:00132 L-lysinoalanine modification from RESID 0 DeltaMass 2544544 PubMed AA0123 RESID cross-link 2 From DeltaMass: Average Mass: -34 PSI-MOD slim (2S)-2-amino-6-((2Xi)-2-amino-2-carboxyethylamino)hexanoic acid (2Xi,9S)-lysinoalanine Lysinoalanine (from Cysteine) Lysinoalanine (Ser-Lys) DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 9 H 15 N 3 O 2 MassAvg 197.23 MassMono 197.116427 Origin K, S Source Natural TermSpec none MOD:00692 MOD:00912 MOD:00916 PSI-MOD MOD:00133 N6-(L-isoglutamyl)-L-lysine A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine. 21863 ChEBI 0 DeltaMass 2461365 PubMed 5637041 PubMed 5656070 PubMed 8598899 PubMed AA0124 RESID Cross-link 2. PSI-MOD slim (S,S)-2-amino-6-[(4-amino-4-carboxybutanoyl)amino]hexanoic acid gamma-(N6-lysyl)glutamic acid Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-...) N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 11 H 17 N 3 O 3 MassAvg 239.27 MassMono 239.126991 Origin K, Q Source Natural TermSpec none MOD:00688 MOD:00907 MOD:00912 MOD:00946 PSI-MOD MOD:00134 N6-glycyl-L-lysine A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine. 21885 ChEBI AA0125 RESID Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. PSI-MOD slim (S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) N6-glycyllysine DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 8 H 14 N 3 O 2 MassAvg 184.22 MassMono 184.108602 Origin G, K TermSpec C-term MOD:00688 MOD:00908 MOD:00912 MOD:00954 PSI-MOD MOD:00135 N-(L-isoaspartyl)-glycine A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoaspartyl)-glycine. 21479 ChEBI 1826288 PubMed AA0126 RESID Cross-link 2. PSI-MOD slim (S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid isoaspartyl glycine Isoaspartyl glycine isopeptide (Gly-Asn) N-beta-aspartylglycine DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 6 H 7 N 2 O 3 MassAvg 155.13 MassMono 155.045667 Origin G, N Source Natural TermSpec N-term MOD:00688 MOD:00903 MOD:00908 MOD:00946 PSI-MOD MOD:00136 pyruvic acid (Cys) A protein modification that effectively converts an L-cysteine residue into pyruvic acid. 10085076 PubMed 3042771 PubMed 8464063 PubMed 9252331 PubMed AA0127 RESID resulting 382 UniMod Pyruvic acid (Cys) DiffAvg -33.10 DiffFormula C 0 H -3 N -1 O 1 S -1 DiffMono -33.003705 Formula C 3 H 3 O 2 MassAvg 71.05 MassMono 71.013304 Origin C Source Natural TermSpec N-term MOD:00905 MOD:01154 PSI-MOD MOD:00137 L-3-phenyllactic acid A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid. 1973541 PubMed AA0128 RESID 7 UniMod site This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. PSI-MOD slim (S)-2-hydroxy-3-phenylpropanoic acid 3-phenyllactic acid Deamidated Deamidation DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 9 H 9 O 2 MassAvg 149.17 MassMono 149.060255 Origin X TermSpec N-term MOD:00914 PSI-MOD MOD:00138 2-oxobutanoic acid A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid. 15023056 PubMed 1680314 PubMed 2253617 PubMed 2764678 PubMed AA0129 RESID 385 UniMod site PSI-MOD slim 2-oxobutanoic acid 2-oxobutanoic acid Ammonia-loss Loss of ammonia DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 4 H 5 O 2 MassAvg 85.08 MassMono 85.028954 Origin X TermSpec N-term MOD:00917 MOD:01160 PSI-MOD MOD:00139 N2-succinyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan. 11857757 PubMed 12175151 PubMed 8471040 PubMed AA0130 RESID 64 UniMod site PSI-MOD slim (S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid N2-succinyltryptophan Succinic anhydride labeling reagent light form (N-term & K) Succinyl DiffAvg 100.07 DiffFormula C 4 H 4 N 0 O 3 DiffMono 100.016044 Formula C 15 H 15 N 2 O 4 MassAvg 287.29 MassMono 287.103182 Origin X TermSpec N-term MOD:00918 PSI-MOD MOD:00140 S-phycocyanobilin-L-cysteine modification from RESID 15617 ChEBI 0 DeltaMass 16644722 PubMed 3208761 PubMed 3838747 PubMed 7918400 PubMed AA0131 RESID 387 UniMod site From DeltaMass: Average Mass: 587 PSI-MOD slim (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione phycobilin cysteine Phycocyanobilin phycocyanobilin phycocyanobilin cysteine adduct S-Phycocyanobilin (on Cysteine) DiffAvg 586.68 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 36 H 43 N 5 O 7 S 1 MassAvg 689.82 MassMono 689.288319 Origin C Source Natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00141 S-phycoerythrobilin-L-cysteine modification from RESID 15618 ChEBI 14588022 PubMed 3208761 PubMed 3838747 PubMed 8876649 PubMed AA0132 RESID 388 UniMod PSI-MOD slim (2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid Phycoerythrobilin phycoerythrobilin phycoerythrobilin cysteine adduct DiffAvg 588.69 DiffFormula C 33 H 40 N 4 O 6 S 0 DiffMono 588.294785 Formula C 36 H 45 N 5 O 7 S 1 MassAvg 691.84 MassMono 691.303970 Origin C Source Natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00142 S-phytochromobilin-L-cysteine modification from RESID 15619 ChEBI 1634523 PubMed 16593380 PubMed 3208761 PubMed 7918400 PubMed AA0133 RESID 389 UniMod PSI-MOD slim 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3-dihydro-(21H,24H)-biline-1,19-dione phytochrome chromophore Phytochromobilin phytochromobilin phytochromobilin cysteine adduct DiffAvg 584.66 DiffFormula C 33 H 36 N 4 O 6 S 0 DiffMono 584.263485 Formula C 36 H 41 N 5 O 7 S 1 MassAvg 687.81 MassMono 687.272669 Origin C Source Natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00143 heme-bis-L-cysteine modification from RESID 17627 ChEBI 5545094 PubMed 8827449 PubMed AA0134 RESID cross-link 2 PSI-MOD slim 2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX [7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate biscysteinyl heme Heme (covalent) DiffAvg 616.49 DiffFormula C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono 616.177298 Formula C 40 Fe 1 H 42 N 6 O 6 S 2 MassAvg 822.77 MassMono 822.195667 Origin C, C Source Natural TermSpec none MOD:00699 MOD:00905 PSI-MOD MOD:00144 heme-L-cysteine modification from RESID 17627 ChEBI 0 DeltaMass 170910 PubMed 192772 PubMed 2536325 PubMed 9535866 PubMed AA0135 RESID 390 UniMod site From DeltaMass: Average Mass: 617 PSI-MOD slim 4-[1-(S-cysteinyl)ethyl]protoporphyrin IX [12-ethenyl-7-((S)-1-[(R)-2-amino-2-carboxy]ethylsulfanyl)ethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate cysteinyl heme Heme heme Heme (covalent; via 1 link) S-Heme (on Cysteine) DiffAvg 616.49 DiffFormula C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono 616.177298 Formula C 37 Fe 1 H 37 N 5 O 5 S 1 MassAvg 719.63 MassMono 719.186482 Origin C Source Natural TermSpec none MOD:00699 MOD:00905 PSI-MOD MOD:00145 tetrakis-L-cysteinyl iron modification from RESID 1303768 PubMed 2244884 PubMed AA0136 RESID cross-link 4 PSI-MOD slim tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-iron DiffAvg 51.81 DiffFormula C 0 Fe 1 H -4 N 0 O 0 S 0 DiffMono 51.903642 Formula C 12 Fe 1 H 16 N 4 O 4 S 4 MassAvg 464.38 MassMono 463.940380 Origin C, C, C, C Source Natural TermSpec none MOD:00738 MOD:00905 PSI-MOD MOD:00146 tetrakis-L-cysteinyl diiron disulfide modification from RESID 2123937 PubMed 6801028 PubMed 7763242 PubMed 8688437 PubMed AA0137 RESID cross-link 4 PSI-MOD slim di-mu-sulfidobis[bis(cysteinato)-kappaS,KappaS-iron] tetrakis(cysteinato)-1kappaS,1kappaS,2kappaS,2kappaS-di-mu-sulfidodiiron DiffAvg 171.79 DiffFormula C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono 171.782725 Formula C 12 Fe 2 H 16 N 4 O 4 S 6 MassAvg 584.36 MassMono 583.819463 Origin C, C, C, C Source Natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00147 hexakis-L-cysteinyl triiron trisulfide modification from RESID 3379067 PubMed 3932661 PubMed 7354058 PubMed AA0138 RESID cross-link 6 PSI-MOD slim tri-mu-sulfidotris(biscysteinato-kappaS-iron) DiffAvg 257.68 DiffFormula C 0 Fe 3 H -6 N 0 O 0 S 3 DiffMono 257.674088 Formula C 18 Fe 3 H 24 N 6 O 6 S 9 MassAvg 876.54 MassMono 875.729195 Origin C, C, C, C, C, C Source Artifact TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00148 tris-L-cysteinyl triiron tetrasulfide modification from RESID 10555576 PubMed 2056535 PubMed 3422475 PubMed 6848518 PubMed 7819255 PubMed 9063899 PubMed AA0139 RESID cross-link 3 PSI-MOD slim mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron mu3-sulfido-tri-mu-sulfidotris(cysteinato-kappaS-iron) tris-L-cysteinyl triiron tetrasulfide C3 cluster tris-L-cysteinyl triiron tetrasulfide cubane form tris-L-cysteinyl triiron tetrasulfide cuboid cluster tris-L-cysteinyl triiron tetrasulfide trigonal cluster DiffAvg 292.77 DiffFormula C 0 Fe 3 H -3 N 0 O 0 S 4 DiffMono 292.669634 Formula C 9 Fe 3 H 12 N 3 O 3 S 7 MassAvg 602.20 MassMono 601.697187 Origin C, C, C Source Natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00149 tetrakis-L-cysteinyl tetrairon tetrasulfide modification from RESID 3351918 PubMed 7803404 PubMed 7819196 PubMed 932007 PubMed AA0140 RESID cross-link 4 PSI-MOD slim tetra-mu3-sulfidotetrakis(S-cysteinyliron) tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetra-mu3-sulfido-tetrahedro-tetrairon DiffAvg 347.61 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.596751 Formula C 12 Fe 4 H 16 N 4 O 4 S 8 MassAvg 760.18 MassMono 759.633489 Origin C, C, C, C Source Natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00150 L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide modification from RESID 10525412 PubMed 12215645 PubMed 12733878 PubMed 1529354 PubMed 8027059 PubMed AA0141 RESID cross-link 2; incidental to RESID:AA0300 PSI-MOD slim nitrogenase iron-molybdenum cofactor DiffAvg 991.57 DiffFormula C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9 DiffMono 993.213065 Formula C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10 MassAvg 1231.85 MassMono 1233.281162 Origin C, H Source Natural TermSpec none MOD:00739 MOD:00743 MOD:00905 MOD:00909 PSI-MOD MOD:00151 L-cysteinyl molybdopterin modification from UniMod and Resid 14527393 PubMed 7878465 PubMed 9428520 PubMed AA0142 RESID 391 UniMod PSI-MOD slim 8-amino-2-(2-amino-2-carboxyethyl)sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene cysteinyl Mo-pterin molybdoenzyme molybdenum cofactor Molybdopterin molybdopterin DiffAvg 520.27 DiffFormula C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 DiffMono 521.884073 Formula C 13 H 16 Mo 1 N 6 O 9 P 1 S 3 MassAvg 623.41 MassMono 624.893258 Origin C Source Natural TermSpec none MOD:00744 MOD:00905 PSI-MOD MOD:00152 S-(8alpha-FAD)-L-cysteine modification from RESID 10220347 PubMed AA0143 RESID 50 UniMod site PSI-MOD slim (R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid 8alpha-(S-cysteinyl)FAD FAD Flavin adenine dinucleotide S-8alpha-FAD cysteine S8aFADCys DiffAvg 783.53 DiffFormula C 27 H 31 N 9 O 15 P 2 S 0 DiffMono 783.141484 Formula C 30 H 36 N 10 O 16 P 2 S 1 MassAvg 886.68 MassMono 886.150669 Origin C Source Natural TermSpec none MOD:00895 MOD:00905 PSI-MOD MOD:00153 3'-(8alpha-FAD)-L-histidine modification from RESID 241294 PubMed 8076 PubMed AA0144 RESID 50 UniMod site PSI-MOD slim (S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid 8alpha-(N(delta)-histidyl)FAD 8alpha-(N3'-histidyl)FAD 8alpha-N1-histidyl FAD [misnomer] FAD Flavin adenine dinucleotide Npros8aFADHis pi-(8alpha-FAD)-histidine pros-(8alpha-FAD)-histidine Pros-8alpha-FAD histidine DiffAvg 783.53 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141484 Formula C 33 H 38 N 12 O 16 P 2 MassAvg 920.67 MassMono 920.200396 Origin H Source Natural TermSpec none MOD:00895 MOD:00909 PSI-MOD MOD:00154 O4'-(8alpha-FAD)-L-tyrosine modification from RESID 0 DeltaMass 7391034 PubMed AA0145 RESID 50 UniMod site From DeltaMass: Average Mass: 783 PSI-MOD slim (S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid 8alpha-(O4'-tyrosyl)FAD FAD Flavin adenine dinucleotide O-8 alpha-Flavin [FAD])- (of Tyrosine) O-8alpha-FAD tyrosine O8aFADTyr DiffAvg 783.53 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141484 Formula C 36 H 40 N 10 O 17 P 2 MassAvg 946.71 MassMono 946.204813 Origin Y Source Natural TermSpec none MOD:00895 MOD:00919 PSI-MOD MOD:00155 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine. 0 DeltaMass 1610822 PubMed 1903612 PubMed 3734192 PubMed AA0146 RESID incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 PSI-MOD slim (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid 3',4'-dihydroxyphenylalanine 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) 3HyTyr L-3'-hydroxytyrosine L-DOPA levodopa DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 9 H 9 N 1 O 3 MassAvg 179.17 MassMono 179.058243 Origin Y Source Natural TermSpec none MOD:00425 MOD:00707 PSI-MOD MOD:00156 oxidation of tyrosine to L-2',4',5'-topaquinone A protein modification that effectively converts an L-tyrosine residue to L-2',4',5'-topaquinone. 21187 ChEBI 10387067 PubMed 1457410 PubMed 1569055 PubMed 2111581 PubMed AA0147 RESID 392 UniMod site PSI-MOD slim (S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid 2',4',5'-topaquinone 2,4,5-trihydroxyphenylalanine quinone 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone L-2,4,5-TOPAquinone Quinone quinone TopaQ DiffAvg 29.98 DiffFormula C 0 H -2 N 0 O 2 DiffMono 29.974179 Formula C 9 H 7 N 1 O 4 MassAvg 193.16 MassMono 193.037508 Origin Y Source Natural TermSpec none MOD:00679 MOD:00919 PSI-MOD MOD:00157 oxidation of tryptophan to L-tryptophyl quinone A protein modification that effectively converts an L-tryptophan residue to L-tryptophan quinone. 0 DeltaMass 2028257 PubMed AA0148 RESID 392 UniMod incidental to RESID:AA0149; incidental to RESID:AA0313 From DeltaMass: Average Mass: 30 PSI-MOD slim (S)-3-(2-amino-2-carboxyethyl)-6,7-indolinedione 6,7 Dione (from Tryptophan) Quinone quinone TQ Tryptophylquinone DiffAvg 29.98 DiffFormula C 0 H -2 N 0 O 2 DiffMono 29.974179 Formula C 11 H 8 N 2 O 3 MassAvg 216.19 MassMono 216.053492 Origin W Source Natural TermSpec none MOD:00679 MOD:00918 PSI-MOD MOD:00158 4'-(L-tryptophan)-L-tryptophyl quinone A protein modification that effectively converts two L-tryptophan residues to 4'-(L-tryptophan)-L-tryptophyl quinone. 20251 ChEBI 0 DeltaMass 2028257 PubMed AA0149 RESID cross-link 2; secondary to RESID:AA0148 From DeltaMass: Average Mass: 28 PSI-MOD slim (S,S)-3-(2-amino-2-carboxyethyl)-4-[3-(2-amino-2-carboxyethyl)-1H-indol-2-yl]-6,7-indolinedione 2,4-BisTrp-6,7-dione (from Tryptophan) 4'-tryptophan-tryptophylquinone 4-(2'-tryptophyl)tryptophan-6,7-dione alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid Tryptophan tryptophylquinone (Trp-Trp) DiffAvg 27.97 DiffFormula C 0 H -4 N 0 O 2 DiffMono 27.958529 Formula C 22 H 16 N 4 O 4 MassAvg 400.39 MassMono 400.117155 Origin W, W Source Natural TermSpec none MOD:00692 MOD:00918 PSI-MOD MOD:00159 O3-phosphopantetheine-L-serine A protein modification that effectively converts an L-serine residue to O3-phosphopantetheine-L-serine. 0 DeltaMass 10320345 PubMed 10997907 PubMed 12057197 PubMed 12869567 PubMed 4568609 PubMed AA0150 RESID 49 UniMod UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 PSI-MOD slim (2R)-4-((2S)-2-amino-2-carboxyethyl)phosphonato-2-hydroxy-N-[3-(2-sulfanylethyl)amino-3-oxopropyl]-3,3-dimethylbutanamide 4'-Phosphopantetheine Phosphopantetheine Phosphopantetheine Phosphopantetheine (covalent) DiffAvg 340.33 DiffFormula C 11 H 21 N 2 O 6 P 1 S 1 DiffMono 340.085794 Formula C 14 H 26 N 3 O 8 P 1 S 1 MassAvg 427.41 MassMono 427.117822 Origin S Source Natural TermSpec none MOD:00916 PSI-MOD MOD:00160 N4-glycosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine. 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151 RESID variant PSI-MOD slim N-linked (GlcNAc) N4GlycoAsn DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 19 N 3 O 7 MassAvg 317.30 MassMono 317.122300 Origin N Source Natural TermSpec none MOD:00006 MOD:00903 PSI-MOD MOD:00161 S-glucosyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine. 1145128 PubMed 15279557 PubMed 5286858 PubMed AA0152 RESID 41 UniMod site PSI-MOD slim (R)-2-amino-3-(beta-D-glucopyranosylsulfanyl)propanoic acid Hex Hexose S-(beta-D-glucopyranosyl)cysteine S-glycosyl-cysteine S-linked (Glc) SGlcCys DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 S 0 DiffMono 162.052823 Formula C 9 H 15 N 1 O 6 S 1 MassAvg 265.28 MassMono 265.062008 Origin C Source Natural TermSpec none MOD:00426 MOD:00433 MOD:00905 PSI-MOD MOD:00162 O5-glucosylgalactosyl-L-hydroxylysine modification from RESID 15149698 PubMed 4288358 PubMed 4319110 PubMed AA0153 RESID 393 UniMod secondary to RESID:AA0028 PSI-MOD slim (2S,5R)-2,6-diamino-5-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxan-2-yl]oxy-hexanoic acid 5-[(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy]-L-lysine Glucosylgalactosyl glucosylgalactosyl hydroxylysine O-linked (Gal-Glc) OGlcGal5HyLys DiffAvg 340.28 DiffFormula C 12 H 20 N 0 O 11 DiffMono 340.100561 Formula C 18 H 32 N 2 O 12 MassAvg 468.45 MassMono 468.195525 Origin K Source Natural TermSpec none MOD:00396 MOD:00476 MOD:00912 PSI-MOD MOD:00163 O-(N-acetylaminogalactosyl)-L-serine modification from RESID 115869 PubMed 16005634 PubMed 3086323 PubMed 8948436 PubMed 9092502 PubMed AA0154 RESID 43 UniMod site PSI-MOD slim (S)-2-amino-3-(alpha-D-2-acetamido-2-deoxygalactopyranosyloxy)propanoic acid HexNAc mucin type O-glycosylserine N-Acetylhexosamine O-linked (GalNAc) O3-(N-acetylgalactosaminyl)serine OGalNAcSer DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 11 H 18 N 2 O 7 MassAvg 290.27 MassMono 290.111401 Origin S Source Natural TermSpec none MOD:00002 MOD:00563 PSI-MOD MOD:00164 O-(N-acetylaminogalactosyl)-L-threonine modification from RESID 16005634 PubMed 1997327 PubMed 3086323 PubMed 8948436 PubMed 9092502 PubMed AA0155 RESID 43 UniMod site PSI-MOD slim (2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxygalactopyranosyloxy)butanoic acid HexNAc mucin type O-glycosylthreonine N-Acetylhexosamine O-linked (GalNAc) O3-(N-acetylgalactosaminyl)threonine OGalNAcThr DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 20 N 2 O 7 MassAvg 304.30 MassMono 304.127051 Origin T Source Natural TermSpec none MOD:00005 MOD:00563 PSI-MOD MOD:00165 1'-mannosyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan. 1482345 PubMed 16150691 PubMed AA0156 RESID PSI-MOD slim (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid 1'-glycosyl-L-tryptophan N-linked (Man) N-mannosyl-tryptophan N1'ManTrp N1-mannosyl-tryptophan DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 17 H 20 N 2 O 6 MassAvg 348.35 MassMono 348.132136 Origin W Source Natural TermSpec none MOD:00006 MOD:00595 MOD:00918 PSI-MOD MOD:00166 O4'-glucosyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine. 15279557 PubMed 3181138 PubMed AA0157 RESID 41 UniMod site PSI-MOD slim (S)-2-amino-3-(4-alpha-glucopyranosyloxy)phenylpropanoic acid Hex Hexose O4'-glycosyl-L-tyrosine O4GlcTyr DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 15 H 19 N 1 O 7 MassAvg 325.31 MassMono 325.116152 Origin Y Source Natural TermSpec none MOD:00396 MOD:00433 MOD:00919 PSI-MOD MOD:00167 N-asparaginyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine. 1824714 PubMed 8276756 PubMed AA0158 RESID PSI-MOD slim GPI-anchor amidated asparagine GPIAsn DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 13 N 3 O 6 P 1 MassAvg 254.16 MassMono 254.054197 Origin N Source Natural TermSpec C-term MOD:00818 MOD:00903 PSI-MOD MOD:00168 N-aspartyl-glycosylphosphatidylinositolethanolamine modification from RESID 7120400 PubMed AA0159 RESID PSI-MOD slim GPI-anchor amidated aspartate GPIAsp DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 12 N 2 O 7 P 1 MassAvg 255.14 MassMono 255.038212 Origin D Source Natural TermSpec C-term MOD:00818 MOD:00904 PSI-MOD MOD:00169 N-cysteinyl-glycosylphosphatidylinositolethanolamine modification from RESID 2897081 PubMed AA0160 RESID PSI-MOD slim GPI-anchor amidated cysteine GPICys DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 S 0 DiffMono 123.008530 Formula C 5 H 12 N 2 O 5 P 1 S 1 MassAvg 243.20 MassMono 243.020454 Origin C Source Natural TermSpec C-term MOD:00818 MOD:00905 PSI-MOD MOD:00170 N-glycyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine. 2341397 PubMed AA0161 RESID PSI-MOD slim GPI-anchor amidated glycine GPIGly DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 4 H 10 N 2 O 5 P 1 MassAvg 197.11 MassMono 197.032733 Origin G Source Natural TermSpec C-term MOD:00818 MOD:00908 PSI-MOD MOD:00171 N-seryl-glycosylphosphatidylinositolethanolamine modification from RESID 2111324 PubMed 8448158 PubMed AA0162 RESID PSI-MOD slim GPI-anchor amidated serine GPISer DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 6 P 1 MassAvg 227.13 MassMono 227.043298 Origin S Source Natural TermSpec C-term MOD:00818 MOD:00916 PSI-MOD MOD:00172 N-alanyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine. 7682556 PubMed 7744038 PubMed AA0163 RESID PSI-MOD slim GPI-anchor amidated alanine GPIAla DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 5 P 1 MassAvg 211.13 MassMono 211.048383 Origin A Source Natural TermSpec C-term MOD:00818 MOD:00901 PSI-MOD MOD:00173 N-threonyl-glycosylphosphatidylinositolethanolamine modification from RESID AA0164 RESID PSI-MOD slim GPI-anchor amidated threonine GPIThr DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 14 N 2 O 6 P 1 MassAvg 241.16 MassMono 241.058948 Origin T Source hypothetical TermSpec C-term MOD:00818 MOD:00917 PSI-MOD MOD:00174 N-glycyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine. 12626404 PubMed 8404891 PubMed AA0165 RESID PSI-MOD slim GPI-like-anchor amidated glycine GSIGly DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 4 H 10 N 2 O 5 P 1 MassAvg 197.11 MassMono 197.032733 Origin G Source hypothetical TermSpec C-term MOD:00466 MOD:00908 PSI-MOD MOD:00175 N-seryl-glycosylsphingolipidinositolethanolamine modification from RESID 12626404 PubMed 2721485 PubMed 8269952 PubMed AA0166 RESID PSI-MOD slim GPI-like-anchor amidated serine GSISer DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 6 P 1 MassAvg 227.13 MassMono 227.043298 Origin S Source Natural TermSpec C-term MOD:00466 MOD:00916 PSI-MOD MOD:00176 O-(phosphoribosyl dephospho-coenzyme A)-L-serine modification from RESID 10924139 PubMed 11052675 PubMed 179809 PubMed 180526 PubMed 368065 PubMed AA0167 RESID 395 UniMod pRibodePcoA PSI-MOD slim O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine O3-(phosphoribosyl dephospho-coenzyme A)-L-serine O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine phosphoribosyl dephospho-coenzyme A Phosphoribosyl dephospho-coenzyme A (covalent) PhosphoribosyldephosphoCoA DiffAvg 881.63 DiffFormula C 26 H 42 N 7 O 19 P 3 S 1 DiffMono 881.146902 Formula C 29 H 47 N 8 O 21 P 3 S 1 MassAvg 968.71 MassMono 968.178931 Origin S Source Natural TermSpec none MOD:00916 PSI-MOD MOD:00177 omega-N-(ADP-ribosyl)-L-arginine modification from RESID 0 DeltaMass 15842200 PubMed 209022 PubMed 3090031 PubMed 3923473 PubMed 6582062 PubMed AA0168 RESID 213 UniMod From DeltaMass: Average Mass: 541 PSI-MOD slim (S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid ADP Ribose addition ADP-Ribosyl ADP-ribosylarginine N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) N-(ADP-ribosyl)- (on Arginine) DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 21 H 33 N 9 O 14 P 2 MassAvg 697.49 MassMono 697.162220 Origin R Source Natural TermSpec none MOD:00752 MOD:00902 PSI-MOD MOD:00178 S-(ADP-ribosyl)-L-cysteine modification from RESID 0 DeltaMass 15842200 PubMed 3863818 PubMed AA0169 RESID 213 UniMod site From DeltaMass: Average Mass: 541 PSI-MOD slim (R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid ADP Ribose addition ADP-Ribosyl ADP-ribosylcysteine S-(ADP-ribosyl)- (on Cysteine) S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 S 0 DiffMono 541.061109 Formula C 18 H 26 N 6 O 14 P 2 S 1 MassAvg 644.44 MassMono 644.070293 Origin C Source Natural TermSpec none MOD:00752 MOD:00905 PSI-MOD MOD:00179 L-glutamyl 5-glycerylphosphorylethanolamine modification from RESID 2511205 PubMed 2569467 PubMed 9252331 PubMed 9662537 PubMed AA0170 RESID 396 UniMod glycerylPE PSI-MOD slim (S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid GlycerylPE glycerylphosphorylethanolamine Glycerylphosphorylethanolamine (covalent) L-glutamyl 5-glycerophosphoethanolamine L-glutamyl 5-glycerophosphorylethanolamine DiffAvg 197.13 DiffFormula C 5 H 12 N 1 O 5 P 1 DiffMono 197.045309 Formula C 10 H 19 N 2 O 8 P 1 MassAvg 326.24 MassMono 326.087902 Origin E Source Natural TermSpec none MOD:00906 PSI-MOD MOD:00180 S-sulfo-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine. 12876326 PubMed 14752058 PubMed 643076 PubMed AA0171 RESID 40 UniMod site PSI-MOD slim (R)-2-amino-3-(sulfosulfanyl)propanoic acid 2-amino-3-(sulfothio)propanoic acid cysteine sulfate thioester O-Sulfonation S-sulfocysteine S-sulfocysteine Sulfo DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 3 H 5 N 1 O 4 S 2 MassAvg 183.21 MassMono 182.965999 Origin C Source Natural TermSpec none MOD:00695 MOD:00777 MOD:00905 PSI-MOD MOD:00181 O4'-sulfo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine. 88 DeltaMass 10226369 PubMed 14752058 PubMed 2303439 PubMed 3778455 PubMed 3801003 PubMed AA0172 RESID 40 UniMod site From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. PSI-MOD slim (S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate O-Sulfonation O4-sulfotyrosine Sulfo Sulfotyrosine Sulphation (of O of Tyrosine) tyrosine sulfate tyrosine-O-sulfonic acid tyrosine-O-sulphonic acid Tyrosinyl Sulphate [misnomer] DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 9 H 9 N 1 O 5 S 1 MassAvg 243.24 MassMono 243.020143 Origin Y Source Natural TermSpec none MOD:00695 MOD:00774 MOD:00919 PSI-MOD MOD:00182 L-bromohistidine modification from RESID 2076468 PubMed 9033387 PubMed AA0173 RESID 340 UniMod site PSI-MOD slim bromination Bromo Bromohistidine DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910513 Formula Br 1 C 6 H 6 N 3 O 1 MassAvg 216.04 MassMono 214.969424 Origin H Source Natural TermSpec none MOD:00754 MOD:00909 PSI-MOD MOD:00183 L-2'-bromophenylalanine modification from RESID 83 DeltaMass 2059627 PubMed 2076468 PubMed 9033387 PubMed AA0174 RESID 340 UniMod site From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa PSI-MOD slim (S)-2-amino-3-(2-bromophenyl)propanoic acid bromination Bromo L-o-bromination of Phe with 79Br o-bromophenylalanine ortho-bromophenylalanine DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910513 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source Natural TermSpec none MOD:00754 MOD:00914 PSI-MOD MOD:00184 L-3'-bromophenylalanine modification from RESID 2076468 PubMed 9033387 PubMed AA0175 RESID 340 UniMod site PSI-MOD slim (S)-2-amino-3-(3-bromophenyl)propanoic acid bromination Bromo m-bromophenylalanine meta-bromophenylalanine DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910513 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source Natural TermSpec none MOD:00754 MOD:00914 PSI-MOD MOD:00185 L-4'-bromophenylalanine modification from RESID 2076468 PubMed 9033387 PubMed AA0176 RESID 340 UniMod site PSI-MOD slim (S)-2-amino-3-(4-bromophenyl)propanoic acid bromination Bromo p-bromophenylalanine para-bromophenylalanine DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910513 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source Natural TermSpec none MOD:00754 MOD:00914 PSI-MOD MOD:00186 3',3'',5'-triiodo-L-thyronine modification from RESID 18258 ChEBI 0 DeltaMass AA0177 RESID 397 UniMod From DeltaMass: Average Mass: 470 PSI-MOD slim (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid 3,3',5-triiodo-L-thyronine 3,5,3'-triiodo-L-thyronine 3,5,3'-Triiodothyronine (from Tyrosine) 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine liothyronine O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine triiodo Triiodothyronine Triiodothyronine DiffAvg 469.78 DiffFormula C 6 H 1 I 3 N 0 O 1 DiffMono 469.716144 Formula C 15 H 10 I 3 N 1 O 3 MassAvg 632.96 MassMono 632.779472 Origin Y Source Natural TermSpec none MOD:00502 MOD:00919 PSI-MOD MOD:00187 L-thyroxine modification from RESID 18332 ChEBI 6704086 PubMed AA0178 RESID 398 UniMod PSI-MOD slim (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid 3',3'',5',5''-tetraiodo-L-thyronine 3,3',5,5'-tetraiodo-L-thyronine 3,5,3',5'-tetraiodo-L-thyronine 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine tetraiodo Thyroxine Thyroxine DiffAvg 595.68 DiffFormula C 6 H 0 I 4 N 0 O 1 DiffMono 595.612787 Formula C 15 H 9 I 4 N 1 O 3 MassAvg 758.85 MassMono 758.676115 Origin Y Source Natural TermSpec none MOD:00755 MOD:00919 PSI-MOD MOD:00188 L-6'-bromotryptophan A protein modification that effectively converts an L-tryptophan residue to L-6'-bromotryptophan. 12118011 PubMed 9030520 PubMed 9033387 PubMed 9434739 PubMed AA0179 RESID 340 UniMod site PSI-MOD slim (S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid 6'-bromotryptophan bromination Bromo DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910513 Formula Br 1 C 11 H 9 N 2 O 1 MassAvg 265.11 MassMono 263.989826 Origin W Source Natural TermSpec none MOD:00754 MOD:00918 PSI-MOD MOD:00189 dehydroalanine (Ser) A protein modification that effectively converts an L-serine residue to dehydroalanine. 0 DeltaMass 10220322 PubMed 1547888 PubMed 1815586 PubMed 2914619 PubMed 7947813 PubMed 8239649 PubMed AA0181 RESID resulting 23 UniMod site 2,3-didehydroalanine (Ser) dHAla(Ser) DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin S Source Natural TermSpec none MOD:00416 MOD:00916 MOD:01168 PSI-MOD MOD:00190 L-threonine dehydrated to (Z)-dehydrobutyrine a protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine 0 DeltaMass 1547888 PubMed 3769923 PubMed AA0182 RESID 23 UniMod site PSI-MOD slim (Z)-2-amino-butenoic acid 2,3-didehydrobutyrine 2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine Dehydrated Dehydration Dehydroamino butyric acid dHyThr methyl-dehydroalanine DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin T Source Natural TermSpec none MOD:00416 MOD:00917 PSI-MOD MOD:00191 (Z)-2,3-didehydrotyrosine a protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine 1347277 PubMed 9252331 PubMed 9631087 PubMed AA0183 RESID 401 UniMod site incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 PSI-MOD slim (Z)-2,3-didehydrogenated tyrosine (Z)-2,3-didehydrotyrosine (Z)-2-amino-3-(4-hydoxyphenyl)propenoic acid 2-amino-3-oxo-butanoic_acid amino-(para-hydroxybenzylidenyl)acetic acid cis-dehydrotyrosine Didehydro green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore Z-dHTyr DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 9 H 7 N 1 O 2 MassAvg 161.16 MassMono 161.047678 Origin Y Source Natural TermSpec none MOD:00706 PSI-MOD MOD:00192 L-serine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine. 21393 ChEBI 1347277 PubMed 9631087 PubMed AA0184 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. PSI-MOD slim 2-[(R)-1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one 5-imidazolinone (Ser-Gly) green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore seryl-5-imidazolinone glycine DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 6 N 2 O 2 MassAvg 126.11 MassMono 126.042927 Origin G, S Source Natural TermSpec none MOD:00691 MOD:00908 MOD:00916 PSI-MOD MOD:00193 L-3-oxoalanine (Cys) a protein modification that effectively converts L-cysteine to L-oxoalanine. 350 DeltaMass 14563551 PubMed 7628016 PubMed 8681943 PubMed 9478923 PubMed AA0185 RESID resulting 402 UniMod 3-oxoalanine (Cys) DiffAvg -18.08 DiffFormula C 0 H -2 N 0 O 1 S -1 DiffMono -17.992806 Formula C 3 H 3 N 1 O 2 MassAvg 85.06 MassMono 85.016378 Origin C Source Natural TermSpec none MOD:01169 PSI-MOD MOD:00194 lactic acid modification from RESID 7607233 PubMed AA0186 RESID 403 UniMod PSI-MOD slim 2-hydroxypropanoic acid alpha-hydroxypropionic acid Lactic acid lactic acid from N-term Ser Ser->LacticAcid DiffAvg -15.01 DiffFormula C 0 H -1 N -1 O 0 DiffMono -15.010899 Formula C 3 H 5 O 2 MassAvg 73.07 MassMono 73.028954 Origin X TermSpec N-term MOD:00916 PSI-MOD MOD:00195 L-alanine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine. 10220322 PubMed AA0187 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. PSI-MOD slim 2-[(S)-1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one active site 5-imidazolinone (Ala-Gly) alanyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 6 N 2 O 1 MassAvg 110.11 MassMono 110.048013 Origin A, G Source Natural TermSpec none MOD:00691 MOD:00901 MOD:00908 PSI-MOD MOD:00196 L-cysteine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine. 1537807 PubMed AA0188 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. PSI-MOD slim 2-[(R)-1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one 5-imidazolinone (Cys-Gly) cysteinyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 5 H 6 N 2 O 1 S 1 MassAvg 142.18 MassMono 142.020084 Origin C, G Source Natural TermSpec none MOD:00691 MOD:00905 MOD:00908 PSI-MOD MOD:00197 2-imino-glutamine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine. 11050230 PubMed 11209050 PubMed AA0189 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. PSI-MOD slim 2,N-didehydroglutaminyl-5-imidazolinone glycine 2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one 2-iminomethyl-5-imidazolinone (Gln-Gly) [2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid fluorescent protein FP583 chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 7 H 7 N 3 O 2 MassAvg 165.15 MassMono 165.053826 Origin G, Q Source Natural TermSpec none MOD:00691 MOD:00907 MOD:00908 PSI-MOD MOD:00198 D-alanine (Ala) A protein modification that effectively converts an L-alanine residue to D-alanine. 15023056 PubMed 7287302 PubMed 7961627 PubMed AA0191 RESID resulting D-Ala(Ala) D-alanine (Ala) DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin A Source Natural TermSpec none MOD:00570 MOD:00862 MOD:00901 PSI-MOD MOD:00199 D-allo-isoleucine A protein modification that effectively converts an L-isoleucine residue to D-allo-isoleucine. 30007 ChEBI 8223491 PubMed AA0192 RESID PSI-MOD slim (2R,3S)-2-amino-3-methylpentanoic acid D-allo-isoleucine D-Ile DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin I Source Natural TermSpec none MOD:00306 MOD:00664 MOD:00910 PSI-MOD MOD:00200 D-methionine A protein modification that effectively converts an L-methionine residue to D-methionine. 29984 ChEBI 16033333 PubMed 2542051 PubMed AA0193 RESID PSI-MOD slim (R)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid D-Met D-methionine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.20 MassMono 131.040485 Origin M Source Natural TermSpec none MOD:00664 MOD:00913 PSI-MOD MOD:00201 D-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine. 29996 ChEBI 1548227 PubMed 1644179 PubMed 2597281 PubMed AA0194 RESID PSI-MOD slim (R)-2-amino-3-phenylpropanoic acid D-Phe D-phenylalanine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 1 MassAvg 147.17 MassMono 147.068414 Origin F Source Natural TermSpec none MOD:00664 MOD:00914 PSI-MOD MOD:00202 D-serine (Ser) A protein modification that effectively converts an L-serine residue to D-serine. 7973665 PubMed AA0195 RESID resulting D-Ser(Ser) D-serine (Ser) DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin S Source Natural TermSpec none MOD:00891 MOD:00916 PSI-MOD MOD:00203 D-asparagine A protein modification that effectively converts an L-asparagine residue to D-asparagine. 29957 ChEBI 1859408 PubMed AA0196 RESID PSI-MOD slim (R)-2-amino-4-butanediamic acid D-alpha-aminosuccinamic acid D-Asn D-asparagine D-aspartic acid beta-amide DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin N Source Natural TermSpec none MOD:00664 MOD:00903 PSI-MOD MOD:00204 D-leucine A protein modification that effectively converts an L-leucine residue to D-leucine. 30005 ChEBI 10461743 PubMed 12135762 PubMed 1358533 PubMed 1548227 PubMed AA0197 RESID PSI-MOD slim (R)-2-amino-4-methylpentanoic acid alpha-aminoisocaproic acid D-Leu D-leucine DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin L Source Natural TermSpec none MOD:00306 MOD:00664 MOD:00911 PSI-MOD MOD:00205 D-tryptophan A protein modification that effectively converts an L-tryptophan residue to D-tryptophan. 29955 ChEBI 8910408 PubMed AA0198 RESID PSI-MOD slim (R)-2-amino-3-(1H-indol-3-yl)propanoic acid alpha-amino-beta-(3-indolyl)propionoic acid D-Trp D-tryptophan DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 11 H 10 N 2 O 1 MassAvg 186.21 MassMono 186.079313 Origin W Source Natural TermSpec none MOD:00664 MOD:00918 PSI-MOD MOD:00206 L-isoglutamyl-polyglycine modification from RESID 21343 ChEBI 10074368 PubMed 16368691 PubMed 7992051 PubMed AA0201 RESID PSI-MOD slim gamma-glutamylpolyglycine DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 7 H 10 N 2 O 4 MassAvg 186.17 MassMono 186.064057 Origin E Source Natural TermSpec none MOD:00906 PSI-MOD MOD:00207 L-isoglutamyl-polyglutamic acid modification from RESID 10747868 PubMed 1680872 PubMed AA0202 RESID PSI-MOD slim gamma-glutamylpolyglutamic acid DiffAvg 129.11 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 10 H 14 N 2 O 6 MassAvg 258.23 MassMono 258.085186 Origin E Source Natural TermSpec none MOD:00906 PSI-MOD MOD:00208 O4'-(phospho-5'-adenosine)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine. 0 DeltaMass 5543675 PubMed AA0203 RESID 405 UniMod site From DeltaMass: Average Mass: 329. PSI-MOD slim (S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid 5'-adenylic-O-tyrosine AMP binding site hydrogen 5'-adenylate tyrosine ester O-5'-Adenosylation ( of Tyrosine) O-AMP-tyrosine O4'-L-tyrosine 5'-adenosine phosphodiester Phosphoadenosine DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 19 H 21 N 6 O 8 P 1 MassAvg 492.38 MassMono 492.115848 Origin Y Source Natural TermSpec none MOD:00919 MOD:01165 PSI-MOD MOD:00209 S-(2-aminovinyl)-D-cysteine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. 3181159 PubMed 3769923 PubMed AA0204 RESID Cross-link 2. PSI-MOD slim (S)-2-amino-3-[((Z)-2-aminovinyl)sulfanyl]propanoic acid (S,Z)-S-(2-aminovinyl)cysteine S-(2-aminovinyl)-D-cysteine (Ser-Cys) DiffAvg -64.04 DiffFormula C -1 H -4 N 0 O -3 S 0 DiffMono -64.016044 Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.19 MassMono 143.027909 Origin C, S TermSpec C-term MOD:00687 MOD:00905 MOD:00916 PSI-MOD MOD:00210 oxidation to L-cysteine sulfenic acid A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid. 41 DeltaMass 10964927 PubMed 2501303 PubMed 8756456 PubMed 9214307 PubMed 9586994 PubMed 9587003 PubMed AA0205 RESID From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). PSI-MOD slim (R)-2-amino-2-carboxyethanesulfenic acid 2-amino-3-sulfenopropanoic acid 3-sulfenoalanine CysOH Cysteine sulfenic acid (-SOH) S-hydroxycysteine Sulfenic Acid (from Cysteine) DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 3 H 5 N 1 O 2 S 1 MassAvg 119.14 MassMono 119.004099 Origin C Source Natural TermSpec none MOD:00708 PSI-MOD MOD:00211 S-glycyl-L-cysteine A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine. 22050 ChEBI 3306404 PubMed AA0206 RESID Cross-link 2. PSI-MOD slim (R)-2-amino-3-(aminoacetyl)sulfanylpropanoic acid glycine cysteine thioester S-(2-amino-1-oxoethyl)cysteine DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 5 H 7 N 2 O 2 S 1 MassAvg 159.19 MassMono 159.022823 Origin C, G TermSpec C-term MOD:00395 MOD:00905 MOD:00908 MOD:00954 PSI-MOD MOD:00212 S-4-hydroxycinnamyl-L-cysteine modification from RESID 7947803 PubMed 7981196 PubMed AA0207 RESID 407 UniMod PSI-MOD slim (S,E)-2-amino-3-[3-(4-hydroxyphenyl)propenoylsulfanyl]propanoic acid 4-hydroxycinnamyl (covalent) cinnamate cysteine thioester Hydroxycinnamyl hydroxycinnamyl S-para-coumaryl-L-cysteine DiffAvg 146.14 DiffFormula C 9 H 6 N 0 O 2 S 0 DiffMono 146.036779 Formula C 12 H 11 N 1 O 3 S 1 MassAvg 249.29 MassMono 249.045964 Origin C Source Natural TermSpec none MOD:00905 PSI-MOD MOD:00213 chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine modification from RESID 1794445 PubMed 1898736 PubMed 3472204 PubMed AA0208 RESID PSI-MOD slim chondroitin 4-sulfate (chondroitin sulfate A) chondroitin 6-sulfate (chondroitin sulfate C) O-linked (Xyl...) (chondroitin sulfate) poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source Natural TermSpec none MOD:00002 PSI-MOD MOD:00214 dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine modification from RESID 2914936 PubMed 3472204 PubMed AA0209 RESID PSI-MOD slim beta-heparin chondroitin sulfate B O-linked (Xyl...) (dermatan sulfate) poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source Natural TermSpec none MOD:00002 PSI-MOD MOD:00215 heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine modification from RESID 3472204 PubMed AA0210 RESID PSI-MOD slim heparin heparitin sulfate O-linked (Xyl...) (heparan sulfate) poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source Natural TermSpec none MOD:00002 PSI-MO